Woods Hole Oceanographic Institution

Jared V Goldstone
Jared V. Goldstone's photoJared V Goldstone

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Research Interests

Evolution of chemical stress response in animals; developmental toxicology; molecular evolution of enzymes; cytochrome P450 evolution and function; molecular modeling of protein-xenobiotic interactions; humans and ocean health; photochemical and biological production of reactive oxygen

  • Ph.D. MIT/WHOI Joint Program, 2002, Chemical Oceanography
  • S.M. MIT, 1996, Inorganic Chemistry
  • B.S. Yale University, 1993, Chemistry

Recent and Important Publications

P450 Evolution

  • C. T. Amemiya, J. Alfoldi, et al (91 authors) The African coelacanth genome provides insights into tetrapod evolution. (2013). Nature. 496, 311–316.
  • D. R. Nelson, J. V. Goldstone, J. J. Stegeman.(2013) The cytochrome P450 genesis locus: The origin and evolution of animal cytochrome P450s. Philosophical Transactions of the Royal Society B Biological Sciences 6;368(1612):2012047.
  • J. V. Goldstone, A. G. McArthur, J. Zanette, T. Parente, M. Jönsson, D. R. Nelson, and J. J. Stegeman. Identification and Developmental Expression of the Full Complement of Cytochrome P450 Genes in Zebrafish BMC Evol. Biol. (2010) 11:643
  • J. J. Stegeman, J. V. Goldstone, M. E. Hahn. Perspectives in Zebrafish as a Model in Environmental Toxicology. In: Zebrafish. S. F. Perry, M. Ekker, A. P. Farrell C. J. Brauner (eds). Elsevier. (2010)
  • J. V. Goldstone, M. E. Jönsson, B. R. Woodin, M. J. Jenny, D. R. Nelson and J. J. Stegeman. CYP1D, a new cytochrome P450 subfamily in vertebrates: Constitutive expression in zebrafish.  Archives of Biochemistry and Biophysics. (2009) 482(1-2): 7-16
  • J. V. Goldstone, H. M. H. Goldstone, A. M. Morrison, A. M. Tarrant, S. E. Kern, B. R. Woodin, and J. J. Stegeman. Cytochrome P450 1 genes in early deuterostomes (tunicates and sea urchins) and vertebrates (chicken and frog): Origin and diversification of the CYP1 gene family. Molecular Biology and Evolution. (2007) 24(12):2619-2631.
  • The Sea Urchin Genome Consortium. The genome of the sea urchin Strongylocentrotus purpuratus. Science (2006) 10 Nov 314:5801, 941 - 952.

PXR function and evolution

  • R. Lille-Langøy, J. V. Goldstone, M. Rusten, M. R. Milnes, R.Male, J. J Stegeman, B.  Blumberg, and A. Goksøyr. Environmental contaminants activate human and polar bear (Ursus maritimus) promiscuous xenobiotic receptors (PXR, NR1I2) differently Toxicol Appl Pharmacol, (2015) 284(1):54-64.
  • A. Kubota, J. V. Goldstone, B. Lemaire, M. Takata, B. R. Woodin, and J. J. Stegeman Pregnane X receptor and aryl hydrocarbon receptor both are involved in transcriptional regulation of pxr, CYP2 and CYP3 genes in developing zebrafish Toxicological Sciences (2015), 143(2):398-407
P450 Function
  • J. V. Goldstone, M. Sundaramoorthy, B. Zhao, M. R. Waterman, J. J. Stegeman and D. C. Lamb. Genetic and structural analyses of cytochrome P450 hydroxylases in sex hormone biosynthesis: Sequential origin and subsequent coevolution Molecular Phylogenetics and Evolution (2016) 94:676-687
  • J. J. Stegeman, L. Behrendt, B. R. Woodin, A. Kubota, B. Lemaire, D. Pompon, J. V. Goldstone, P. Urban. Functional characterization of zebrafish cytochrome P450 1 family proteins expressed in yeast. Biochim Biophys Acta (2015) 1850(11) 2340-2352.
  • Morrison AM, Goldstone JV, Lamb DC, Kubota A, Lemaire B, Stegeman JJ. Identification, modeling and ligand affinity of early deuterostome CYP51s, and functional characterization of recombinant zebrafish sterol 14α-demethylase (2013) Biochim Biophys Acta 1840(6):1825-36
  • J. C. Prasad, J. V. Goldstone, C. J. Camacho, J, J. Stegeman and S. Vajda. Ensemble modeling of substrate binding to cytochromes P450: analysis of catalytic differences between CYP1A orthologues. Biochemistry (2007) 46(10):2640-54.
Defensome and comparative evolution
  • M. C. Celander, J. V. Goldstone, N. D. Denslow, T. Iguchi, P. Kille, R. D. Meyerhoff, B. A. Smith, T. H. Hutchinson, J. R. Wheeler. Species Extrapolation for the 21st Century. Environmental Toxicology and Chemistry (2011)
  • J. V. Goldstone. Environmental sensing and response genes in Cnidaria: the chemical defensome in the sea anemone Nematostella vectensis. Cell Biology and Toxicology (2008) 24(6) 483-502. 66(1):15-18.
  • J.V. Goldstone, A. Hamdoun, B.J. Cole, M. Howard-Ashby, D. W. Nebert, M. Scally, M. Dean, D. Epel, M.E. Hahn, J.J. Stegeman. The chemical defensome: Environmental sensing and response genes in the Strongylocentrotus purpuratus genome. Developmental Biology (2006) 300:1 366-384.


  • Zanette J, Jenny MJ, Goldstone JV, Parente T, Woodin BR, Bainy AC, J. J. Stegeman. (2013) Identification and expression of multiple CYP1-like and CYP3-like genes in the bivalve mollusk Mytilus edulis. Aquat Toxicol. 128-129:101-12.

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