The algae Alexandrium fundyense are notorious for producing a toxin that accumulates in shellfish such as clams, mussels, and oysters, leading to paralytic shellfish poisoning in humans. The microscopic plants are naturally distributed in New England waters, but in some years—2005, for example—a confluence of factors causes major blooms that spread down the coast and force officials to close shellfish beds.
To protect consumers, and the livelihoods of shellfishermen from Maine to Massachusetts, researchers would like to able to forecast when and where Alexandrium will bloom and to explain how and why. In a project sponsored by the Woods Hole Center for Oceans and Human Health, scientists Dennis McGillicuddy and Ruoying He of Woods Hole Oceanographic Institution have developed a mathematical model of Alexandrium dynamics—a series of equations that captures the physical and biological factors involved in harmful algal blooms in New England.
Millions and millions of calculations
Working with colleagues in the biology lab of WHOI Senior Scientist Don Anderson, McGillicuddy and He entered a range of factors into their model: the speeds and directions of ocean currents, water temperature and salinity, winds, surface heat exchanges, tides, river runoff, and the distribution and behavior of Alexandrium cells in the water and in seafloor sediments. The team—aided by WHOI researchers Valery Kosnyrev, Olga Kosnyreva, and Larry Anderson—also incorporated other computer models that describe waterborne nutrients, solar radiation, and large-scale motions in the North Atlantic Ocean.
“The beauty of a numerical model,” McGillicuddy said, “is that it can be used to investigate extraordinarily complex systems by posing the problem in terms of a few guiding principles expressed as mathematical equations.”
Plug numbers into the equations, and the model develops a big picture of how the algae spread as a result of the interactions of all those variables. Using a 32-processor “mini-supercomputer,” as He calls it, it can take two days to make all of the calculations necessary to simulate three months of Alexandrium dynamics at more than a million different points in the Gulf of Maine.
How does a bloom end?
The project has been under way for several years, but the work grew more intense and fruitful in 2005. A devastating bloom provoked researchers from WHOI and a dozen federal and state agencies to launch a substantial effort to gather observations of ocean conditions during the event. That fieldwork has allowed He and McGillicuddy to run an extensive “hindcast” of the 2005 bloom; that is, they were able to plug real environmental data into their computer model and see if it could reproduce what actually happened.
“We wanted to compare the model against new observations to see if we really understood the system or if we were just fooling ourselves,” said McGillicuddy.
The model successfully captured how intense spring northeasterly winds and prodigious river runoff, coupled with a huge seed population of Alexandrium cysts, blossomed into a red tide that blanketed New England waters from Canada’s Bay of Fundy to Martha’s Vineyard. The event had an estimated $20 million impact on the seafood industry in New England, according to researchers at the WHOI Marine Policy Center.
The principal flaw in the model’s 2005 projection is that it could not replicate the end of the bloom, which occurred in July. “What processes regulate the end of a bloom and make it shut down?” said He. “We just don’t know enough yet about mortality in Alexandrium, and we are still trying to improve the modeling of this process.”
But the team was encouraged enough to try to track the 2006 season as it develops. Though they are not willing to make public predictions, He and McGillicuddy have been plugging in field observations this spring, letting their model run into the future, and then seeing how well it did. So far, their computerized bloom seems to jibe with the milder blooming realities of 2006.
This research is supported NOAA’s Center for Sponsored Coastal Ocean Research and by the National Science Foundation and the National Institute of Environmental Health Sciences through the Woods Hole Center for Oceans and Human Health.
Finding risks and remedies from the sea
With a rising tide of harmful algal blooms and waterborne pathogenic microbes causing illnesses and closing beaches and shellfish beds, policymakers recognized a growing need to examine links between the oceans and human health. But few links existed between oceanogaphers and scientists specializing in human health.
In 2004, two federal scientific agencies that rarely interacted embarked on a groundbreaking collaboration, which sparked a cascade of novel partnerships. The National Science Foundation’s Division of Ocean Sciences and the National Institute of Environmental Health Sciences created four Centers for Oceans and Human Health (COHH) around the country, including one in Woods Hole, Mass. Each center harnessed the expertise and resources of scientists from several institutions and disciplines to study “risks and remedies from the sea” (the remedies being potential pharmaceuticals from marine sources).
The Woods Hole Center for Oceans and Human Health, for example, has brought together physical oceanographers, biological oceanographers, microbiologists, and genomics experts from Woods Hole Oceanographic Institution (WHOI) , the Marine Biological Laboratory, and the Massachusetts Institute of Technology, said John Stegeman, director of the center and a WHOI biologist.
“The ocean is a turbulent, fluid medium that’s changing all the time,” said Dennis McGillicuddy, a WHOI physical oceanographer and the center’s deputy director. “To make significant progress in health concerns, we have to grapple with how physics, biology, and chemistry intersect and interact. It’s really a fundamentally new direction for this research.”
In its first two years, the Woods Hole COHH launched several investigations on algae, bacteria, viruses, and other organisms that threaten to compromise the safety of our seafood supply and the commercial and recreational use of coastal waters.