From molecules to cells to ecosystems: Integrating Computational Structure-Function Analyses for the (Meta)Genome-scale Modeling of Metabolic Networks


Thursday, February 2, 2012
Redfield Auditorium - 12:00 Noon
Dr. Ying Zhang
Postdoctoral Scholar
Department of Biology, WHOI

The advent of genome sequencing and many high-throughput technologies has enabled the development of computational and experimental tools to investigate various biological processes in a cell. At the same time, it has also highlighted the difficulty in integrating complex information on the hundreds to thousands of different molecules that compose even the smallest cellular network. In this talk, I will present ways to achieve such integration using the example of a marine hyperthermophilic bacterium, Thermotoga maritima. I will also discuss plans to take this approach to the ecosystem level by performing integrated studies on the microbial communities at the deep-sea hydrothermal vents.