10th International Symposium on Cytochrome P450 Biodiversity and BiotechnologySunday, October 3, 20101400- Registration Open 1730-1845 Dinner 1900-1915 Welcome - John Stegeman (Woods Hole Oceanographic) Opening Keynote Lecture1915-1930 Tsuneo Omura - Introduction of Michael Waterman 1930-2030 Michael Waterman, Vanderbilt University, USA Unexpected properties of P450s 2030-2230 Welcome Reception (Swope Center) Monday, October 4, 2010Session: Structural evolutionChairs: David Nelson (University of Tennessee) and Eric Johnson (Scripps Research Institute) Focus: Phylogenetic and structural comparisons of P450s 0830-0900 David Nelson, University of Tennessee, USA Evolution of animal P450s: Single gene origin and tandem duplication 0900-0930 Stephen Sligar, University of Illinois, USA Structure and Function Across the P450 Landscape 0930-1000 Eric Johnson, Scripps Research Institute, USA Vertebrate P450 Structural Evolution and Conservation 1000-1030 Coffee Break 1030-1100 Joanna Wilson, McMaster University, Canada Phylogenetic and Functional Analyses of the Cytochrome P450 Families 2 and 4 1100-1130 Walter Müller, University of the Free State, South Africa Carotenoid metabolizing cytochrome P450 monooxygenases from extremophiles 1130-1200 Dmitri Davidov, University of California at San Diego, USA Cytochrome P450 from Photobacterium profundum, a deep-sea bacterium, reveals tightened control of water accessibility of the active site evolved in the piezophyle 1200-1300 Lunch Session: Plants: P450 functions in development and defenseChairs: Daniele Werck-Reichhart (CNRS, France) Focus: Novel functions and regulatory processes of plant P450s in synthetic and catabolic pathways 1300-1330 Anne Osbourn, John Innes Center, Norwich, UK Operon-like gene clusters for adaptive evolution in plants 1330-1400 Toni Kutchan, Washington University, USA P450s in alkaloid formation 1400-1430 Daisaku Ohta, Osaka Prefecture University, Japan Transcriptional cross-pathway regulation involved in balancing different secondary metabolisms in Arabidopsis 1430-1500 Coffee Break 1500-1530 Birger Lindberg Møller, University of Copenhagen, Denmark Functioning dependent metabolons 1530-1600 Daniele Werck-Reichhart, CNRS-Strasbourg, France The phenylpropanoid metabolon: new insight into the membrane-protein and protein-protein and interactions. 1600-1630 Christoph Crocoll, Max Planck Institute for Chemical Ecology (, Germany The route to thymol and carvacrol formation: CYP71D178-D182 from oregano, thyme and marjoram 1645-1830 Poster Session I and Reception (Swope Center)1830-1930 Dinner Session: P450 Bioengineering IChair: Birger Lindberg Møller (University of Copenhagen, Denmark) Focus: Applications for generating pharmaceuticals and other materials 2000-2030 Rita Bernhardt, University of Saarland Engineering the regio-selectivity of steroid hydroxylation by CYP106A2 2030-2100 Vlada Urlacher, University of Stuttgart Optimization of bacterial cytochrome P450 monooxygenases for biocatalysis Tuesday, October 5, 2010Session: Insects: P450 functions in development and defenseChairs: Rene Feyereisen (INRA-CNRS) and Mary Schuler (University of Illinois) Focus: Novel functions and regulatory processes of insect P450s in synthetic and catabolic processes 0830-0900 Rene Feyereisen, INRA-Sophia Antipolis, France Comparative analysis of insect CYPomes 0900-0930 Mary Schuler, University of Illinois, USA Perspectives on the insect P450s tackling natural and synthetic xenobiotics 0930-1000 Christopher Keeling, University of British Columbia, Canada The P450 gene family of the mountain pine beetle 1000-1030 Coffee Break 1030-1100 Claus Tittiger, University of Nevada, USA On the evolution of pheromone-biosynthetic and resin-detoxification P450s in pine bark beetles 1100-1130 Niels Jensen, University of Copenhagen, Denmark Biosynthesis of cyanogenic defense compounds in plants and insects: a case of convergent evolution 1130-1200 Mark Paine, Liverpool School of Tropical Medicine, UK P450s and insecticide resistance: of man and mosquitoes 1200-1300 Lunch 1300-1700 Free time and exploring 1700-1830 Poster Session II and Reception (Swope Center)1830-1930 Dinner Session: Bioengineering IIChair: Rita Bernhardt (University of Saarland) Focus: Applications for generating pharmaceuticals and other materials 2000-2030 Andrew Munro, University of Manchester, UK Enzymology and Biodiversity of Cytochrome P450: Redox Partner Fusion Enzymes 2030-2100 Gianfranco Gilardi, University of Torino, Italy Bioelectrochemistry of P450 enzymes 2100-2130 Kenneth Jensen, University of Copenhagen, Denmark Light-driven Cytochrome P450 Hydroxylations Wednesday, October 6, 2010Session: Insights in structure and mechanism of P450sChairs: Paul Ortiz de Montellano (University of California at San Francisco) and Thomas Poulos (University of California at Irvine) Focus: Structural features of P450 active sites and catalytic mechanisms 0830-0900 Thomas Poulos, University of California at Irvine, USA The Ferryl Intermediate and Crystallography: the Good, the Bad, and the Ugly 0900-0930 Michael Green, Pennsylvania State University, USA Cytochrome P450 Compound I: Capture, Characterization, and C-H Bond Activation 0930-1000 Larissa Podust, University of California at San Francisco, USA Diversity of P450 catalysis in the biosynthesis of natural products 1000-1030 Coffee Break 1030-1100 Thomas Pochapsky, Brandeis University, USA NMR-based Insights into Substrate Recognition in Cytochrome P450 1100-1130 Young-Tae Lee, Scripps Research Institute, USA Three clusters of conformational states in P450cam suggest a mechanism for substrate recognition by conformational selection 1130-1200 Ilia Denisov, University of Illinois, USA Mechanistic Studies of Membrane-bound Cytochromes P450 in Nanodiscs 1200-1230 Max Cryle, Max Planck Institute for Medical Research, Germany What Roles do Carrier Proteins Play in Cytochrome P450/Carrier Protein Systems? 1230-1330 Lunch Session: Microbial and fungal P450sChairs: Steve Kelley (Swansea University) and Andrew Munro (University of Manchester) Focus: Evolution, structure and function in microbial and fungal taxa 1300-1330 Paul Ortiz de Montellano, University of California at San Francisco, USA Mycobacterium tuberculosis cytochrome P450 in sterol utilization 1330-1400 Kirsty McLean, Manchester University, UK Structure of cholesterol oxidase P450s from Mycobacterium tuberculosis 1400-1430 Ljerka Lah, National Institute of Chemistry, Slovenia Integrated Study of Redox Partners in Fungal Cytochrome P450 Systems 1430-1500 Coffee Break 1500-1530 Steve Kelly, Swansea University, Wales, UK Azole antifungal agents, CYP51 and resistance in the clinic 1530-1600 Galina Lepesheva, Vanderbilt University, USA Structural basis for the CYP51 family conservation and drug targetability 1600-1630 Hans Cools, Rothamsted Research, Harpenden, UK Recent evolution of P450 sterol 14á-demethylase (CYP51) of the wheat pathogen Mycosphaerella graminicola in response to selection by azole fungicides 1700-2200 Reception and Banquet Thursday, October 7, 2010Ecological and environmental applicationsChairs: Jed Goldstone (Woods Hole Oceanographic Institution) and Hideo Ohkawa (Fukuyama University) 0830-0900 Neil Bruce, University of York, UK A staple diet of explosives: environmental applications and insight into the structure and function of the unique explosive degrading cytochrome P450 XplA 0900-0930 Hideo Ohkawa, Fukuyama University, Japan Phytoremediation and phytomonitoring based on recombinant P450s and AhRs 0930-1000 Jagjit Yadav, University of Cincinnati, USA Genome-to-function characterization of novel P450 monooxygenases in white rot fungus 1000-1030 Coffee Break 1030-1100 Hisato Iwata, Ehime University, Japan Regulation and Catalytic Function of Avian CYP1A: Interspecies Similarities and Differences 1100-1130 Philippe Urban, CNRS, France Broad Scale Substrate Selectivity of Novel Cytochrome P450 1C1, 1C2, and 1D1 Enzymes of Zebrafish Danio rerio
1145-1300 Lunch ---Conference ends---Last updated: October 26, 2010 | |||||||||||||
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