Please note: You are viewing the unstyled version of this website. Either your browser does not support CSS (cascading style sheets) or it has been disabled. Skip navigation.

Final Program

  Email    Print  PDF  Change text to small (default) Change text to medium Change text to large

10th International Symposium on Cytochrome P450 Biodiversity and Biotechnology

Sunday, October 3, 2010

1400-                           Registration Open

1730-1845                   Dinner

1900-1915                   Welcome - John Stegeman (Woods Hole Oceanographic)

Opening Keynote Lecture

1915-1930                   Tsuneo Omura - Introduction of Michael Waterman

1930-2030                   Michael Waterman, Vanderbilt University, USA

                                    Unexpected properties of P450s

2030-2230                               Welcome Reception   (Swope Center)

Monday, October 4, 2010

Session: Structural evolution

Chairs: David Nelson (University of Tennessee) and Eric Johnson (Scripps Research Institute)

Focus: Phylogenetic and structural comparisons of P450s

0830-0900                   David Nelson, University of Tennessee, USA

                                    Evolution of animal P450s: Single gene origin and tandem duplication

0900-0930                   Stephen Sligar, University of Illinois, USA

                                    Structure and Function Across the P450 Landscape

0930-1000                   Eric Johnson, Scripps Research Institute, USA

                                    Vertebrate P450 Structural Evolution and Conservation

1000-1030                               Coffee Break

1030-1100                   Joanna Wilson, McMaster University, Canada

                                    Phylogenetic and Functional Analyses of the Cytochrome P450 Families 2 and 4

1100-1130                   Walter Müller, University of the Free State, South Africa

                                    Carotenoid metabolizing cytochrome P450 monooxygenases from extremophiles

1130-1200                   Dmitri Davidov, University of California at San Diego, USA

                                  Cytochrome P450 from Photobacterium profundum, a deep-sea bacterium, reveals tightened control of water accessibility of the active site evolved in the piezophyle

1200-1300                               Lunch

Session:  Plants: P450 functions in development and defense

Chairs: Daniele Werck-Reichhart (CNRS, France)

Focus: Novel functions and regulatory processes of plant P450s in synthetic and catabolic pathways

1300-1330                   Anne Osbourn, John Innes Center, Norwich, UK

                                    Operon-like gene clusters for adaptive evolution in plants

1330-1400                   Toni Kutchan, Washington University, USA

                                    P450s in alkaloid formation

1400-1430                   Daisaku Ohta, Osaka Prefecture University, Japan

                                    Transcriptional cross-pathway regulation involved in balancing different secondary metabolisms in Arabidopsis

1430-1500                               Coffee Break

1500-1530                   Birger Lindberg Møller, University of Copenhagen, Denmark

                                    Functioning dependent metabolons   

1530-1600                   Daniele Werck-Reichhart, CNRS-Strasbourg, France

                                    The phenylpropanoid metabolon: new insight into the membrane-protein and protein-protein and interactions.

1600-1630                   Christoph Crocoll, Max Planck Institute for Chemical Ecology (, Germany

                                    The route to thymol and carvacrol formation: CYP71D178-D182 from oregano, thyme and marjoram

1645-1830                   Poster Session I and Reception (Swope Center)

1830-1930                   Dinner

Session: P450 Bioengineering I

Chair: Birger Lindberg Møller (University of Copenhagen, Denmark)

Focus: Applications for generating pharmaceuticals and other materials

2000-2030                   Rita Bernhardt, University of Saarland

                                    Engineering the regio-selectivity of steroid hydroxylation by CYP106A2

2030-2100                   Vlada Urlacher, University of Stuttgart

                                    Optimization of bacterial cytochrome P450 monooxygenases for biocatalysis

Tuesday, October 5, 2010

Session: Insects: P450 functions in development and defense

Chairs: Rene Feyereisen (INRA-CNRS) and Mary Schuler (University of Illinois)

Focus: Novel functions and regulatory processes of insect P450s in synthetic and catabolic processes

0830-0900                   Rene Feyereisen, INRA-Sophia Antipolis, France

                                    Comparative analysis of insect CYPomes

0900-0930                   Mary Schuler, University of Illinois, USA

                                    Perspectives on the insect P450s tackling natural and synthetic xenobiotics

0930-1000                   Christopher Keeling, University of British Columbia, Canada    

                                    The P450 gene family of the mountain pine beetle

1000-1030                               Coffee Break

1030-1100                   Claus Tittiger, University of Nevada, USA

                                    On the evolution of pheromone-biosynthetic and resin-detoxification P450s in pine bark beetles

1100-1130                   Niels Jensen, University of Copenhagen, Denmark

                                    Biosynthesis of cyanogenic defense compounds in plants and insects: a case of convergent evolution

1130-1200                   Mark Paine, Liverpool School of Tropical Medicine, UK

                                    P450s and insecticide resistance: of man and mosquitoes

1200-1300                               Lunch

1300-1700                             Free time and exploring

1700-1830                   Poster Session II and Reception (Swope Center)

1830-1930                               Dinner

Session: Bioengineering II

Chair: Rita Bernhardt (University of Saarland)

Focus: Applications for generating pharmaceuticals and other materials

2000-2030                   Andrew Munro, University of Manchester, UK

                                    Enzymology and Biodiversity of Cytochrome P450: Redox Partner Fusion Enzymes

2030-2100                   Gianfranco Gilardi, University of Torino, Italy

                                    Bioelectrochemistry of P450 enzymes

2100-2130                   Kenneth Jensen, University of Copenhagen, Denmark

                                    Light-driven Cytochrome P450 Hydroxylations

Wednesday, October 6, 2010

Session: Insights in structure and mechanism of P450s

Chairs: Paul Ortiz de Montellano (University of California at San Francisco) and Thomas Poulos (University of California at Irvine)

Focus: Structural features of P450 active sites and catalytic mechanisms

0830-0900                   Thomas Poulos, University of California at Irvine, USA

                                   The Ferryl Intermediate and Crystallography: the Good, the Bad, and the Ugly

0900-0930                   Michael Green, Pennsylvania State University, USA

                                   Cytochrome P450 Compound I: Capture, Characterization, and C-H Bond Activation

0930-1000                   Larissa Podust, University of California at San Francisco, USA

                                    Diversity of P450 catalysis in the biosynthesis of natural products

1000-1030                               Coffee Break

1030-1100                   Thomas Pochapsky, Brandeis University, USA

                                    NMR-based Insights into Substrate Recognition in Cytochrome P450

1100-1130                   Young-Tae Lee, Scripps Research Institute, USA

                                    Three clusters of conformational states in P450cam suggest a mechanism for substrate recognition by conformational selection

1130-1200                   Ilia Denisov, University of Illinois, USA

                                    Mechanistic Studies of Membrane-bound Cytochromes P450 in Nanodiscs

1200-1230                   Max Cryle, Max Planck Institute for Medical Research, Germany

                                    What Roles do Carrier Proteins Play in Cytochrome P450/Carrier Protein Systems?

1230-1330                               Lunch

Session:  Microbial and fungal P450s

Chairs: Steve Kelley (Swansea University) and Andrew Munro (University of Manchester)

Focus: Evolution, structure and function in microbial and fungal taxa

1300-1330                   Paul Ortiz de Montellano, University of California at San Francisco, USA

                                    Mycobacterium tuberculosis cytochrome P450 in sterol utilization

1330-1400                   Kirsty McLean, Manchester University, UK

                                    Structure of cholesterol oxidase P450s from Mycobacterium tuberculosis

1400-1430                   Ljerka Lah, National Institute of Chemistry, Slovenia

                                    Integrated Study of Redox Partners in Fungal Cytochrome P450 Systems

1430-1500                               Coffee Break

1500-1530                   Steve Kelly, Swansea University, Wales, UK

                                    Azole antifungal agents, CYP51 and resistance in the clinic

1530-1600                   Galina Lepesheva, Vanderbilt University, USA

                                    Structural basis for the CYP51 family conservation and drug targetability              

1600-1630                   Hans Cools, Rothamsted Research, Harpenden, UK

                                    Recent evolution of P450 sterol 14á-demethylase (CYP51) of the wheat pathogen Mycosphaerella graminicola in response to selection by azole fungicides

1700-2200                               Reception and Banquet

Thursday, October 7, 2010

Ecological and environmental applications

Chairs: Jed Goldstone (Woods Hole Oceanographic Institution) and Hideo Ohkawa (Fukuyama University)         

0830-0900                   Neil Bruce, University of York, UK

                                   A staple diet of explosives: environmental applications and insight into the structure and function of the unique explosive degrading cytochrome P450 XplA

0900-0930                   Hideo Ohkawa, Fukuyama University, Japan

                                    Phytoremediation and phytomonitoring based on recombinant P450s and AhRs

0930-1000                   Jagjit Yadav, University of Cincinnati, USA

                                    Genome-to-function characterization of novel P450 monooxygenases in white rot fungus

1000-1030                               Coffee Break

1030-1100                   Hisato Iwata, Ehime University, Japan

                                    Regulation and Catalytic Function of Avian CYP1A: Interspecies Similarities and Differences

1100-1130                   Philippe Urban, CNRS, France

                                    Broad Scale Substrate Selectivity of Novel Cytochrome P450 1C1, 1C2, and 1D1 Enzymes of Zebrafish Danio rerio


1145-1300                          Lunch

---Conference ends---

Last updated: October 26, 2010

whoi logo

Copyright ©2007 Woods Hole Oceanographic Institution, All Rights Reserved, Privacy Policy.
Problems or questions about the site, please contact