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Woods Hole Oceanographic Institution

Jed Goldstone
Jared V. Goldstone's photoJed Goldstone
Research Specialist
Biology

Contact Information:
Work: 508 289 4823
jgoldstone@whoi.edu
Building: Redfield 352

http://www.mit.edu/people/jedgold/home.html

Mailing Address:
Mailstop 32
Woods Hole Oceanographic Institution
Woods Hole, MA 02543

Research Interests
1. Evolution of the cytochrome P450 (CYP) superfamily in animals, including evolution of major biochemical pathways 2. Function of the genomic complement of CYP enzymes in aquatic species and determination of the chemical space occupied by various CYP subfamilies. 3. Biological production of reactive oxygen species (ROS; includes superoxide, hydrogen peroxide, and hydroxyl radical) and effects of oxidative stress

Education
  • Ph.D. MIT/WHOI Joint Program, 2002, Chemical Oceanography
  • S.M. MIT, 1996, Inorganic Chemistry
  • B.S. Yale University, 1993, Chemistry


Recent Publications
2013 and in press
  • Morrison AM, Goldstone JV, Lamb DC, Kubota A, Lemaire B, Stegeman JJ. Identification, modeling and ligand affinity of early deuterostome CYP51s, and functional characterization of recombinant zebrafish sterol 14α-demethylase (2013) Biochim Biophys Acta epub 19Dec.
  • Timme-Laragy, A., J. V. Goldstone, B. R. Imhoff, J. J. Stegeman, M. E. Hahn, and J. M. Hansen. Glutathione redox dynamics and expression of glutathione-related genes in the developing embryo. (2013) Free Rad Biol Med 65:89-101.
  • A. Kubota, A. C.D. Bainy, B. R. Woodin, J. V. Goldstone and J. J. Stegeman. The cytochrome P450 2AA gene cluster in zebrafish (Danio rerio): expression of CYP2AA1 and CYP2AA2 and response to phenobarbital-type inducers. (2013) Toxicol Appl Pharmacol 272:172-179.
  • Zanette J, Jenny MJ, Goldstone JV, Parente T, Woodin BR, Bainy AC, J. J. Stegeman. (2013) Identification and expression of multiple CYP1-like and CYP3-like genes in the bivalve mollusk Mytilus edulis. Aquat Toxicol. 128-129:101-12.
  • C. T. Amemiya, J. Alfoldi, et al (91 authors) The African coelacanth genome provides insights into tetrapod evolution. (2013). Nature. 496, 311–316.
  • D. R. Nelson, J. V. Goldstone, J. J. Stegeman.(2013) The cytochrome P450 genesis locus: The origin and evolution of animal cytochrome P450s. Philosophical Transactions of the Royal Society B Biological Sciences 6;368(1612):20120474
2012
  • H.M.H. Goldstone, S. Tokugawa, J. J. Schelzinger, J. V. Goldstone, J. J. Stegeman. EZR1: A novel family of highly expressed retrotransposon deletion derivatives induced by TCDD and regulated by NF-κB in embryos of zebrafish (Danio rerio). (2012) Zebrafish 9(1):15-25
  • A. R. Timme-Laragy, S. I. Karchner, D.G. Franks, M. J. Jenny,  J.V. Goldstone, M. E. Hahn  Nrf2b: A novel zebrafish paralog of the oxidant-responsive transcription factor Nrf2 (2012) J. Biol. Chem. 287(7):4609-4627
  • J. V. Goldstone and J. J. Stegeman. Methodological approaches to cytochrome P450 profiling in embryos. (2012) in Methods in Molecular Biology (J. Hansen, ed.)
2011
  • T. E. Parente, MF Rebelo, ML da-Silva, BR Woodin, J.V. Goldstone, PM Bisch, FJ Paumgartten, JJ Stegeman. Structural features of cytochrome P450 1A associated with the absence of EROD activity in liver of the loricariid catfish Pterygoplichthys sp. (2011) Gene. Epub Aug 5.
  • B. Shrestha, J. M. Reed, P. T. B. Starks, G. E. Kaufman, J. V. Goldstone, M. E. Roelke, S. J. O'Brien, K.-P. Koepfli, L. G. Frank, and M. H. Court (2011) Evolution of a major drug metabolizing enzyme defect in the domestic cat and other Felidae: Phylogenetic timing and the role of hypercarnivory PLoS One 6(3):e18046.
  • Kubota A, Stegeman JJ, Goldstone JV, Nelson DR, Kim EY, Tanabe S, Iwata H. Cytochrome P450 CYP2 genes in the common cormorant: Evolutionary relationships with 130 diapsid CYP2 clan sequences and chemical effects on their expression. Comp Biochem Physiol C Toxicol Pharmacol. (2011) 153(3):280-9.
  • K. Gao., I. Brand, J.V. Goldstone, M.E .Jönsson . Cytochrome P450 1A, 1B, and 1C mRNA induction patterns in three-spined stickleback exposed to a transient and a persistent inducer. Comp Biochem Physiol C Toxicol Pharmacol. (2011) ePub 25 Feb
  • M. E. Jönsson , C. Berg, J. V. Goldstone, J. J. Stegeman.  New CYP1 genes in the frog Xenopus (Silurana) tropicalis: Induction patterns and effects of AHR agonists during development Toxicol Appl Pharmacol (2011) 250(2):170-83
  • M. C. Celander, J. V. Goldstone, N. D. Denslow, T. Iguchi, P. Kille, R. D. Meyerhoff, B. A. Smith, T. H. Hutchinson, J. R. Wheeler. Species Extrapolation for the 21st Century. Environmental Toxicology and Chemistry(2011)
2010
  • J. V. Goldstone, A. G. McArthur, J. Zanette, T. Parente, M. Jönsson, D. R. Nelson, and J. J. Stegeman. Identification and Developmental Expression of the Full Complement of Cytochrome P450 Genes in Zebrafish BMC Evol. Biol. (2010) 11:643
  • K. E. Whalen, J. V. Goldstone, M. E. Hahn. Cytochrome P450 diversity and induction by gorgonian allelochemicals in the marine gastropod Cyphoma gibbosum. BMC Biology. (2010) 10:24
  •  M. C. K. Leung, J. V. Goldstone, W. A. Boyd, J. H. Freedman, J. N. Meyer Caenorhabditis elegans generates biologically relevant levels of genotoxic metabolites from aflatoxin B1 but not benzo[a]pyrene in vivo. Toxicol. Sci. (2010). 118(2):444-53
  • K. E. Whalen, E. E. Sotka, J. V. Goldstone, M. E. Hahn. The role of multixenobiotic transporters in molluscan predators as defense mechanisms against dietary chemical stress. Comp Biochem. Physiol. (2010) 52(3):288-300
  • J. J. Stegeman, J. V. Goldstone, M. E. Hahn. Perspectives in Zebrafish as a Model in Environmental Toxicology. In: Zebrafish. S. F. Perry, M. Ekker, A. P. Farrell C. J. Brauner (eds). Elsevier. (2010)
  • Jönsson M. E., K. Gao, J. A. Olsson, J. V. Goldstone, I. Brandt. Induction patterns of  new CYP1 genes in environmentally exposed rainbow trout. Aquatic Toxicology (2001) 98(4) 311-321.
  • L. Behrendt, M. E. Jonsson, J. V. Goldstone, and J. J. Stegeman. Induction of cytochrome P450 1 genes and stress response genes in zebrafish embryos exposed to ultraviolet radiation. Aquatic Toxicology (2010) 98(1), 74-82.
  • M. C. Celander, J. V. Goldstone, N. D. Denslow, T. Iguchi, P. Kille, R. D. Meyerhoff, B. A. Smith, T. H. Hutchinson, J. R. Wheeler. Species Extrapolation for the 21st Century. Environmental Toxicology and Chemistry (in press)

2009

  • J. Zannette, J. V. Goldstone, Afonso C. D. Bainy, and J. J. Stegeman. New cytochrome P450 genes in bivalves – Identification of CYPs from mussel and oyster ESTs. Marine Environmental Research (2009) Epub 17 Nov.

  • J. Zannette, M. J. Jenny, J. V. Goldstone,  B. R. Woodin, Lauren A. Watka, Afonso C. D. Bainy, and J. J. Stegeman.  New Cytochrome P450 1B1, 1C2 and 1D1 Genes in the Killifish Fundulus heteroclitus: Basal Expression and Response of Five Killifish CYP1s to the AHR Agonist PCB126. Aquatic Toxicology. (2009) 93(4), 234-43.

  • J. V. Goldstone, M. E. Jönsson, B. R. Woodin, M. J. Jenny, D. R. Nelson and J. J. Stegeman. CYP1D, a new cytochrome P450 subfamily in vertebrates: Constitutive expression in zebrafish.  Archives of Biochemistry and Biophysics. (2009) 482(1-2): 7-16

2008
  • R. M. Gould, T Oakley, J. V. Goldstone, J. C. Dugas, S. T. Brady, A. Gow. Myelin sheaths are formed with proteinsthat originated in vertebrate lineages. Neuron Glia Biology. (2008)
  • J. V. Goldstone. Environmental sensing and response genes in Cnidaria: the chemical defensome in the sea anemone Nematostella vectensis. Cell Biology and Toxicology (2008) 24(6) 483-502. 
  • K. E. Whalen, D. Morin, C. Y. Lin, R. S. Tjeerdema, J. V. Goldstone, M. E. Hahn. Proteomic identification, biochemical characterization and cDNA cloning of glutathione S-transferases from the generalist marine gastropod, Cyphoma gibbosum. Archives of Biochemistry and Biophysics. (2008) 478(1):7-17.
  • Abad, P. et al (56 co-authors) Plant parasitism in metazoans: insight from the Meloidogyne incognita nematode genome. Nature Biotechnology. (2008) 26(8):909-15.
  • J. V. Goldstone and J. J. Stegeman. Gene Structure of the Novel Cytochrome P4501D1 Genes in Stickleback (Gasterosteus aculeatus) and Medaka (Oryzias latipes). Marine and Environmental Research. (2008) 66(1):19-20.
  • G. de Toledo-Silva, M. N. Siebert; I. D. Medeiros, T. Sincero, M. O. Moraes, J. V. Goldstone, A. C. D. Bainy. Cloning a new Cytochrome P450 isoform (CYP356A1) from the oyster Crassostrea gigas. Marine Environmental Research. (2008) 66(1):15-18. 
2007
  • J. V. Goldstone, H. M. H. Goldstone, A. M. Morrison, A. M. Tarrant, S. E. Kern, B. R. Woodin, and J. J. Stegeman. Cytochrome P450 1 genes in early deuterostomes (tunicates and sea urchins) and vertebrates (chicken and frog): Origin and diversification of the CYP1 gene family. Molecular Biology and Evolution. (2007) 24(12):2619-2631.
  •  Jönsson, M. E., R. Orrego, B. R. Woodin, J V. Goldstone, and J. J. Stegeman. Basal and 3,3’,4,4’,5-pentachlorobiphenyl-induced expression of cytochrome P450 1A, 1B, and 1C genes in zebrafish. Toxicology and Applied Pharmacology (2007) 221(1):29-41.
  • J. C. Prasad, J. V. Goldstone, C. J. Camacho, J, J. Stegeman and S. Vajda. Ensemble modeling of substrate binding to cytochromes P450: analysis of catalytic differences between CYP1A orthologues. Biochemistry (2007) 46(10):2640-54.
2006
  • The Sea Urchin Genome Consortium. The genome of the sea urchin Strongylocentrotus purpuratus. Science (2006) 10 Nov 314:5801, 941 - 952.
  • J.V. Goldstone, A. Hamdoun, B.J. Cole, M. Howard-Ashby, D. W. Nebert, M. Scally, M. Dean, D. Epel, M.E. Hahn, J.J. Stegeman. The chemical defensome: Environmental sensing and response genes in the Strongylocentrotus purpuratus genome. Developmental Biology (2006) 300:1 366-384.
  • Verslyke, T., J. V. Goldstone, and J, J. Stegeman. Isolation and phylogeny of novel urochordate clan 3 cytochrome P450 genes. Molecular Phylogenetics and Evolution (2006). 40(3), 760-71.
  • Schlezinger, J. J, W. D. J. Struntz, J. V. Goldstone, J. J. Stegeman. Uncoupling of cytochrome P450 1A and stimulation of reactive oxygen species production by co-planar polychlorinated biphenyl congeners. Aquatic Toxicology (2006). 77(4), 422-32.
2005
  • Godard C. A. J., J. V. Goldstone*, M. S. Said, R. L. Dickerson, B.R. Woodin, and J. J. Stegeman. The New Vertebrate CYP1C Family: Cloning of New Subfamily Members and Phylogenetic Analysis. Biochemical and Biophysical Research Communications (2005), 331(4), 1016-1024. *co-first author.
pre-2005
  • (7 papers)

Full reference list from PubMed:
http://www.ncbi.nlm.nih.gov/sites/myncbi/collections/public/1R_oy8i4bEbkW5-Cjp2Bij3Q-/?sort=date&direction=ascending



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