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This Week's Buttery Specials

*Some prices have changed due to the recent increase in meals tax
Monday
Chicken Tenders w/ Fries and Side Greens
SOUP: Chicken Tortellini   
Sandwiches, Pizza, Salad Bar


Tuesday
Sausage and Pepper Sub w/ Chips and Cole Slaw
Soup: Kale  
Sandwiches, Pizza, Salad


Wednesday
Meat Lasagna and Ceasar Salad  
Soup: Lentil
Sandwiches, Pizza, Salad Bar


Thursday
Pork Chop Suey Over Rice and Broccoli
Soup: French Onion
Sandwiches, Pizza, Salad Bar


Friday
Baked Salmon w/ Rice Pilaf and Vegetable
Soup: Clam Chowder
Sandwiches, Pizza, and Salad Bar


» More about the Buttery

Jed Goldstone Jed Goldstone
Research Specialist
Biology

Office Phone: +1 508 289 4823
jgoldstone@whoi.edu

» Personal Site
» Lab/Group Site

WHOI Mailing Address:
Woods Hole Oceanographic Institution
266 Woods Hole Rd.
MS# 32
Woods Hole, MA 02543-1050

Education

BS 1993 Yale University, Chemistry
SM 1996 MIT, Inorganic Chemistry
PhD 2002 MIT-WHOI Joint Program, Chemical Oceanography

Research Interests

mechanism and evolution of cytochromes P450; ecotoxicology; molecular evolution in marine animals; oxidative stress in aquatic organisms

Research Statement

My research is focused on the cytochromes P450 (CYPs), a superfamily of mono-oxidase heme proteins involved in the primary metabolism of various endogenous and xenobiotic compounds. The natural history of CYPs dates back perhaps 3 billion years, and they occur variously in archaea, eubacteria and eukaryota. Functional and evolutionary relationships among many CYPs remain unclear between vertebrate taxa, and more so between vertebrates and invertebrates. I am interested in the evolution of the effective chemical space occupied by the CYP superfamily in animals, primarily in aquatic organisms. By combining phylogenomics with ensemble modeling of discovered genes of possible toxicological relevance I aim to predict the characteristics of CYP active sites that lead to either metabolism (with possible metabolic activation of compounds to toxic intermediates) or the uncoupling of CYP catalytic activity, leading to the generation of oxidative stress.

Awards

National Research Service Award (NIH)

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