Jared (Jed) Goldstone

 

Redfield 352 MS#32                                                                                                   jedgold@alum.mit.edu

Woods Hole Oceanographic Institution                                                             Phone: (508) 289-4823

Woods Hole, MA 02543                                                                                             Fax: (508) 457-2134

 

 

Education        Ph.D. in Chemical Oceanography                                           February 2002

                       Massachusetts Institute of Technology & Woods Hole Oceanographic Institute Joint Program in Oceanography. Thesis advisor: Bettina Voelker

                      

                       S.M in Inorganic Chemistry                                                   June 1996

                       Massachusetts Institute of Technology

                      

                       B.S in Chemistry                                                                     June 1993

                       Yale University  

                      

Experience      NIH Kirschstein NRSA Postdoctoral Fellow             September 2003-present

                       Postdoctoral Investigator                                                        July 2002-September 2003

                       Department of Biology, Woods Hole Oceanographic Institution

                       Senior Scientist John Stegeman. The involvement of ROS in the toxic mechanisms of polyhalogenated aromatic hydrocarbons. Molecular evolution of CYP genes.

 

                       Research Assistant Professor                                                February 2002-July 2002

                       University of Maryland, College Park

                       Professor Neil Blough. Modeled the photobleaching spectra of humic substances.

 

                       Graduate Reseach Assistant                                                  Sept. 1996-February 2002

                       MIT Department of Civil and Environmental Engineering 

                       Woods Hole Oceanographic Institute

                       Professor Bettina Voelker, Sr. Scientist Oliver Zafiriou (Woods Hole)

                       Photochemistry in natural waters. Reactive oxygen photochemistry.

 

                       Graduate Research Assistant                                                Sept. 1993-June 1996

                       MIT Department of Chemistry

                       Professor Alan Davison. Synthesis of cis-dioxorhenium oxygen atom transfer catalysts, technetium radiopharmaceutical characterization.

 

                       Research Assistant                                                                 June 1992- July 1993

                       Yale University Department of Chemistry               

                       Professor Robert Crabtree. Synthesis of rhodium-containing alkane activation catalysts.

 

                       Research Assistant                                                                 June 1991 - Dec. 1991

                       Bigelow Laboratory for Ocean Sciences

                       West Boothbay Harbor, ME and McMurdo Station, Antarctica

                       Drs. Patrick Neale and Michael Lesser. Participant in Research Experience for Undergraduates (REU) Program of the NSF. Effects of UV radiation on the photosynthesis of marine phytoplankton – development of action spectra for inhibition of photosynthesis.

 

 

 

 

Teaching         Teaching Assistant                                                                  Sept. 1997-Dec. 1997

Experience      MIT Department of Civil and Environmental Engineering 

                       Aquatic Chemistry (1.76)

                       MIT Department of Chemistry                                              Sept. 1993- May 1994

                       Introduction to Chemical Science (5.11), Inorganic Chemistry I (5.03)

 

Professional    American Chemical Society, American Society of Limnology and Oceanography,

Societies         American Geophysical Union, The Oceanographic Society, The Society for Free Radical Biology and Medicine, The International Society for the Study of Xenobiotics, Society of Toxicology

 

Professional    Reviewer for Aquatic Toxicology; Deep Sea Research; Photochemistry and Photobiology; Estuarine,

Activities         Coastal and Shelf Science. Founded annual WHOI Postdoctoral Symposium.

                       Co-founded the WHOI Postdoctoral Association. First postdoctoral member of the WHOI Academic Council.

 

Honors           Ruth L. Kirschstein National Research Service Award

                       Dissertations Symposium in Chemical Oceanography (DISCO-XVII) invited participant

                       Ralph M. Parsons Graduate Fellowship

                       United States Navy Antarctic Service Medal

                       National Science Foundation Antarctic Service Award

 

Publications     Prasad, J., J. V. Goldstone, J, J. Stegeman and S. Vajda. Flexible docking to multiple

                       homology models explains the substrate binding differences of fish and human

                       cytochrome P4501A1s. Biochemistry (submitted)

 

                       Verslyke, T., J. V. Goldstone, and J, J. Stegeman. Isolation and phylogeny of novel urochordate clan 3 cytochrome P450 genes. Molecular Phylogenetics and Evolution (in press).

 

                       Schlezinger, J. J, W. D. J. Struntz, J. V. Goldstone, J. J. Stegeman. Uncoupling of cytochrome P450 1A and stimulation of reactive oxygen species production by co-planar polychlorinated biphenyl congeners. Aquatic Toxicology (in press).

 

                       Godard C. A. J., J. V. Goldstone*,  M. S. Said, R. L. Dickerson, B.R. Woodin,  and J. J. Stegeman. The New Vertebrate CYP1C Family: Cloning of New Subfamily Members and Phylogenetic Analysis. Biochemical and Biophysical Research Communications, 331(4), 1016-1024 (2005). *co-first author.

 

                       Goldstone, J. V., R. Del Vecchio, B. M. Voelker, and N. V. Blough. A multicomponent model of CDOM photobleaching. Photochemistry and Photobiology, 80, 52-60 (2004).

 

                       Pullin, M. J., S. Bertilsson, J. V Goldstone, and B. M. Voelker. Photo-induced changes in dissolved organic matter bioavailability: formation of low molecular weight organic acids and other substrates. Limnology and Oceanography, 49, 2011-2022 (2004).

 

                       Goldstone, J. V., M. J. Pullin, S. Bertilsson, and B. M. Voelker. Reactions of hydroxyl radical with humic substances: Bleaching, mineralization, and production of bioavailable carbon substrates. Environmental Science and Technology, 36 (3), 364-372 (2002).

 

                       Goldstone, J. V. and B. M. Voelker. The chemistry of superoxide in seawater: CDOM associated sink of superoxide in coastal waters. Environmental Science and Technology, 34 (6), 1043-1048 (2000).

 

                       Mahmood A., M. H. Kuchma, E. Freiberg, J. V. Goldstone., A. Davison, A. G. Jones. Functionalized tetradentate N2S2 ligands and their technetium-99 and rhenium complexes: synthesis, spectroscopy, and structural characterization. In Technetium, Rhenium, and Other Metals in Chemistry and Nuclear Medicine. Vol 5. (1998)  253-257.

 

                       Mahmood A., M. H. Kuchma, J. V. Goldstone, C. Morse, A. Davison, A. G. Jones. An N2S2 tetradentate chelate for solid-phase synthesis: evaluation in solution andsolid phase and characterization of technetium-99 complexes. In Technetium, Rhenium, and Other Metals in Chemistry and Nuclear Medicine. Vol 5. (1998)  71-76.

 

                       Neale P. J., M. P. Lesser , J. J. Cullen, J. Goldstone.  Detecting UV-induced inhibition of

                       photosynthesis in Antarctic phytoplankton. Antarctic Journal of The United States, 27, 122-124  (1992).

 

Manuscripts    Goldstone, J. V.,  H. M. H. Goldstone, A. M. Morrison, A. M. Tarrant, S. E. Kern, J. Y.

in prep.           Wilson, B. R. Woodin, and J. J. Stegeman. Evolution and diversity of cytochromes P450 Family 1 (CYP1) genes. Manuscript in preparation.

 

                       Goldstone, J. V., Yang, M., and J. J. Stegeman. Stimulated ROS production in a PCB-resistant Fundulus heteroclitus population. To be submitted to Aquatic Toxicology.

                      

                       Goldstone, J. V. and J. J. Stegeman. Kinetics and subcellular localization of reactive oxygen production by CYP1A in fish and mice. Manuscript in preparation.

                      

Thesis             Ph.D. Direct and indirect photoreactions of chromophoric dissolved organic matter: Roles of

Titles               reactive oxygen species and iron.

                       S. M. Rhenium (VII) cis-dioxo complexes. Synthesis and characterization of  rhenium complexes for oxygen atom transfer catalysis.

                       B.S. Synthesis of bis-pyrrolo-2-methyl-sulfone as a ligand for rhodium-catalyzed alkane activation.

 

Extended        Goldstone, J. V., R. Del Vecchio, B. M. Voelker, and N. V. Blough. A multicomponent

Abstracts        model of CDOM photobleaching. Extended Abstracts of Papers of the American Chemical Society. 225:055-ENVR Part 1 (March 23 2003).

 

                       Goldstone, J. V. and B. M. Voelker. CDOM associated sink of superoxide in coastal waters. Extended Abstracts of Papers of the American Chemical Society. 216:057-ENVR Part 1 (Aug 23 1998).

 

Conference     J. V. Goldstone, H. M. Handley Goldstone, A. M. Morrison, A. Tarrant,

Papers and      S. E. Kern, B. R. Woodin, J. J. Stegeman. Functional evolution of the cytochrome

Invited            P450 1 gene family: evidence of a pre-vertebrate origin. Pollutant Responses In Marine

Talks              Organisms (PRIMO XIII). June 2005. Platform presentation.

                      

                       J. V. Goldstone, M. Yang, J. J. Stegeman. Stimulation of reactive oxygen production by liver microsomes from different populations of Fundulus heteroclitus. Pollutant Responses In Marine Organisms (PRIMO XIII). June 2005. Poster.

 

                       T. Verslycke, J. V. Goldstone and J. J. Stegeman Isolation and phylogeny of four novel CYP3A genes from the ascidian Ciona intestinalis. Pollutant Responses In Marine Organisms (PRIMO XIII). June 2005. Poster.

                      

                       J. V. Goldstone and John J. Stegeman CYP1A inactivation and stimulation of reactive oxygen production by planar halogenated aromatic hydrocarbons. 14th International Conference on Cytochrome P450s. June 2005. Poster.

 

                       Reactive oxygen species in the toxic mechanisms of dioxins and PCBs in vertebrate systems. Bowdoin College. October 2004. Invited talk.

 

                       Goldstone, J.V. and J. J. Stegeman, Quantification of ROS production and  enzyme inactivation of CYP 1A by polychlorinated biphenyls and by 2,3,7,8- tetrachlorodibenzo p-dioxins. Toxicology Sciences 78 (1): 1630 Suppl. S MAR 2004. Society of Toxicology, March, 2004.

 

                       Goldstone, J.V. Photochemistry of dissolved organic matter:  The roles of reactive oxygen species in bleaching, mineralization, and the alteration of bioavailability. University of Connecticut, Avery Point. October, 2003. Invited talk.

 

                       Goldstone, J.V. and J. J. Stegeman, Quantification of ROS production and  enzyme inactivation

                       of CYP 1A by polychlorinated biphenyls and by 2,3,7,8- tetrachlorodibenzo-p-dioxins. Drug

                       Metab. Rev. 35 S2 (2003). Presented at the XII North American ISSX Meeting.

 

                       Prasad, J. C., S. Vajda, J.V. Goldstone, C.J. Camacho, J. J. Stegeman. Differences in substrate binding between mammalian and fish cytochrome P450 1As predicted by comparative modeling and flexible docking. Drug Metab. Rev. 35 S2 (2003). Presented at the XII North American ISSX Meeting.

 

                       Goldstone, J.V. and Stegeman , J. J. Quantification of ROS production and  enzyme inactivation of CYP 1A from scup (Stenotomus chrysops) by polychlorinated biphenyls and by 2,3,7,8-tetrachlorodibenzo-p-dioxins. Pollutant Responses In Marine Organisms (PRIMO XII). May 2003.

 

                       Goldstone, J.V. Reactive oxygen in marine chemistry and toxicology: two examples. Great Lakes WATER Institute and Medical College of Wisconsin (3 invited talks). April 2003.

 

                       Goldstone, J. V., R. Del Vecchio, B. M. Voelker, and N. V. Blough. A multicomponent model of CDOM photobleaching. American Chemical Society. March 2003.

 

                       Goldstone, J. V., Blough, N. V., and Stegeman , J. J. Quantification of ROS production and enzyme inactivation of CYP 1A by chlorinated biphenyls and dibenzo-p-dioxins. Toxicology Sciences 72 (1): 1630 Suppl. S MAR 2003. Society of Toxicology, March, 2003. Platform session.

 

                       Goldstone, J. V. Direct and indirect photoreactions of chromophoric dissolved organic matter: Roles of  reactive oxygen species and iron. DISCO XVII, May 2002.

 

                       Goldstone, J. V., and B. M. Voelker. Reactions of hydroxyl radical with humic substances: Bleaching and mineralization. Ocean Sciences, February 2002.

 

                       Goldstone, J. V., R. Del Vecchio, B. M. Voelker, and N. V. Blough. A multicomponent model of CDOM photobleaching. Ocean Sciences, February 2002.

 

                       Goldstone J. V. and B. M. Voelker. Iron effects on the photochemistry of chromophoric dissolved organic matter in estuarine water. Pacifichem, December 2000.

 

                       Goldstone, J. V. The chemistry of superoxide in seawater: CDOM associated sink of superoxide in coastal waters. Woods Hole Oceanographic Institution. February 2000.

 

                       Goldstone, J. V. and B. M. Voelker. February 2000. Does Fe catalyze photobleaching of chromophoric dissolved organic matter in coastal seawater? Ocean Sciences, February 2000.

 

                       Goldstone, J. V.and B. M. Voelker. The chemistry of superoxide in seawater: CDOM associated sink of superoxide in coastal waters. Gordon Research Conference, June 1998. Poster.