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Google Scholar Link for the Saito Laboratory


Mackey, K.M., A.F. Post, M.R. McIlvin, G.A. Cutter, S. John, M.A. Saito.  Divergent responses of Atlantic coastal and oceanic Synechococcus to iron limitation. Proceedings of the National Academy of Sciences. 112:32. 9944–9949, doi: 10.1073/pnas.1509448112

Hutchins, D.A., Nathan S. Walworth, Eric A. Webb, Mak A. Saito, Dawn Moran, Matthew R. McIlvin, Jasmine Gale, and Fei-Xue Fu. 2015. Irreversibly increased nitrogen fixation in Trichodesmium experimentally adapted to elevated carbon dioxide. Nature. doi:10.1038/ncomms9155

Saito, M. A.; Dorsk, A.; Post, A. F.; McIlvin, M.; Rappé, M. S.; DiTullio, G.; Moran, D. 2015. Needles in the Blue Sea: Sub‐Species Specificity in Targeted Protein Biomarker Analyses Within the Vast Oceanic Microbial Metaproteome. Proteomics. DOI: 10.1002/pmic.201400630

Jill Sohm, Nathan Ahlgren, Zachary Thomson, Cheryl Williams, James Moffett, Mak Saito, and Eric Webb, Gabrielle Rocap. 2015. Co-occurring Synechococcus ecotypes occupy four major oceanic regimes defined by temperature, macronutrients, and iron. ISME Journal. doi: 10.1038/ismej.2015.115

Alyson E Santoro, Christopher L Dupont, R Alex Richter, Matthew T Craig, Paul Carini, Matthew R McIlvin, Youngik Yang, William D Orsi, Dawn M Moran, Mak A Saito. 2015. Genomic and proteomic characterization of “Candidatus Nitrosopelagicus brevis”: An ammonia-oxidizing archaeon from the open ocean. Proceedings of the National Academy of Sciences. 201416223.

Tristan J Horner, Helen M Williams, James R Hein, Mak A Saito, Kevin W Burton, Alex N Halliday, Sune G Nielsen. Persistence of deeply sourced iron in the Pacific Ocean. Proceedings of the National Academy of Sciences. 201420188.

Katherine RM Mackey, Chia-Te Chien, Anton F Post, Mak A Saito, Adina Paytan. 2015. Rapid and gradual modes of aerosol trace metal dissolution in seawater. Frontiers in Microbiology. 5, 794.


Mak A. Saito, Matthew R. McIlvin, Dawn M. Moran, Tyler J. Goepfert, Giacomo R. DiTullio, Anton F. Post, Carl H. Lamborg. 2014. Multiple nutrient stresses at intersecting Pacific Ocean biomes detected by protein biomarkers. Science, Vol. 345 No. 6201, pp. 1173-1177. DOI: 10.1126/science.1256450. [Abstract | Reprint | Full Text]

AD Cox, AE Noble, MA Saito. 2014. Cadmium enriched stable isotope uptake and addition experiments with natural phytoplankton assemblages in the Costa Rica Upwelling Dome. Marine Chemistry 166, 70-81.

Elizabeth D Swanner, Noah J Planavsky, Stefan V Lalonde, Leslie J Robbins, Andrey Bekker, Olivier J Rouxel, Mak A Saito, Andreas Kappler, Stephen J Mojzsis, Kurt O Konhauser. Cobalt and marine redox evolution.  2014. Earth and Planetary Science Letters 390, 253-263.

Nathan A. Ahlgren, Abigail Noble, Alison Patton, Kathryn Roache-Johnson, Laurel Jackson, Daniela Robinson, Lisa Moore, Mak Saito, Gabrielle Rocap. The unique trace metal and macronutrient conditions of the Costa Rica upwelling dome support a distinct and dense community of Synechococcus. 2014. Limnology and Oceanography. 59 (6), 2166-2184.


Moore, C.M., Mills, M.M., Arrigo, K.R., Berman-Frank, I., Bopp, L., Boyd,P.W., Galbraith, E.D., Geider, R.J., Guieu, C., Jaccard, S.L., Jickells, T.D., LaRoche, J., Lenton, T., Mahowald, N.M., Marañón, E., Marinov, I., Moore,J.K., Nakatsuka, T., Oschlies, A., Saito, M.A., Thingstad, T.F., Tsuda, A.,Ulloa, O. and Wallace, D. 2013. Oceanic nutrient limitation: processes, patterns and potential for change. Nature Geosciences.

Alysia Cox* and Mak Saito. 2013. Proteomic responses of oceanic Synechococcus WH8102 to phosphate and zinc scarcity and cadmium additions. Frontiers in Microbiological Chemistry. 4:387. doi: 10.3389/fmicb.2013.00387

Abigail E. Noble*, Dawn M. Moran, Andrew E. Allen, and Mak A. Saito. 2013. Dissolved and particulate trace metal micronutrients under the McMurdo Sound seasonal sea ice: basal sea ice communities as a capacitor for iron. Frontiers in Microbiological Chemistry. doi: 10.3389/fchem.2013.00025

Mackey, KRM, K Caldiera, A Grossman, D Moran, M McIlvin, A Paytan, & M Saito. 2013. Effect of temperature on photosynthesis and growth in diverse marine Synechococcus strains. Plant Physiology. DOI:10.1104/pp.113.221937

Saito, M.A., A.E. Noble, T. J. Goepfert, C.H. Lamborg, W.J. Jenkins. 2013. Slow-spreading submarine ridges in the South Atlantic as a significant oceanic iron source. 2013 | DOI: 10.1038/NGEO1893.  Nature Geosciences.

Erin M. Bertrand, Dawn M. Moran, Matthew R. McIlvin, Jeffrey M. Hoffman, Andrew E. Allen, and Mak A. Saito. 2013. Methionine synthase interreplacement in diatom cultures and communities.  Limnology and Oceanography.

J. Daphne Aguirre, Hillary M. Clark, Matthew McIlvin, Christine Vazquez, Shaina L. Palmere, Dennis Grab, J. Seshu, Mak Saito, and Valeria C. Culotta. 2013. A Manganese-Rich Environment Supports Superoxide Dismutase Activity in the Lyme Disease Pathogen, Borrelia burgdorferi. Journal of Biological Chemistry.

L. J . ROBBINS, S. V. LALONDE, M. A. SAITO, N. J . PLANAVSKY, A. M. MLOSZEWSKA, E. PECOITS, C. SCOTT, C. L. DUPONT, A. KAPPLER7 AND K. O. KONHAUSER. 2013. Authigenic iron oxide proxies for marine zinc over geological time and implications for eukaryotic metallome evolution. Geobiology. DOI: 10.1111/gbi.12036.


Bertrand EM*, Allen AE, Dupont CL, Norden-Krichmar T, Bai J, Saito MA. 2012. Impact of Cobalamin Starvation on Diatom Molecular Physiology and the Identification of a Novel Cobalamin Acquisition Protein. Proc. Natl. Acad. Sci.

Noble, A.E., C.H. Lamborg,  D. Ohnemus,  P.J. Lam, K. T.J. Goepfert, C.I. Measures, C.H. Frame, K.L. Casciotti, G.R.DiTullio, J. Jennings, and M.A. Saito. 2012. Basin-scale plumes of cobalt, iron, and manganese emanating from the Benguela-Angola front in the South Atlantic Ocean. Limnology and  Oceanography.

Alexander H, Jenkins BD, Rynearson TA, Saito MA, Mercier ML and Dyhrman ST (2012) Identifying reference genes with stable expression from high throughput sequence data. Frontiers in Aquatic Microbiology. 3:385. doi: 10.3389/fmicb.2012.00385

Katherine RM Mackey, Kathryn Roberts, Michael W Lomas, Mak A Saito, Anton F Post, Adina Paytan. 2012. Variable solubility and ecological impact of atmospheric phosphorus deposition. Environ. Sci. Technol.

Mak A. Saito. 2012. The Rise of Oxygen and Aerobic Biochemistry. Structure. 20:1. 1–2.

Gregory F. de Souza, Ben C. Reynolds, Jörg Rickli, Martin Frank, Mak Saito, Loes J. A. Gerringa and Bernard Bourdon. 2012. Southern Ocean control of silicon stable isotope distribution in the deep Atlantic Ocean. Global Biogeochemical Cycles.

Sonya T. Dyhrman, Bethany D. Jenkins, Tatiana A. Rynearson, Mak A. Saito, Melissa L. Mercier, Harriet Alexander, LeAnn P. Whitney, Andrea Drzewianowski, Vladimir V. Bulygin, Erin M. Bertrand, Zhijin Wu, Claudia Benitez-Nelson, Abigail Heithoff. 2012 Coordination in the transcriptome and proteome of the diatom Thalassiosira pseudonana reveals a diverse phosphorus stress response. PLoS One.

Jakuba, R., M.A. Saito, J.W. Moffett , Y. Xu. 2012. Dissolved zinc in the subarctic North Pacific and Bering Sea: Its distribution, speciation, and importance to primary producers. Global Biogeochemical Cycles.


Mak Saito, Vladimir Bulygin, Dawn Moran, Craig Taylor, and Christopher Scholin. 2011. Examination of Microbial Proteome Preservation Techniques Applicable to Autonomous Environmental Sample Collection. Frontiers in Aquatic Microbiology.

Saito, M.A., E.M. Bertrand, V. Bulygin, D. Moran, S. Dutkiewicz, F.M. Monteiro, M.J. Follows, F.W. Valois, J.B. Waterbury.  2011. Iron Conservation by Reduction of Metalloenzyme Inventories in the Marine Diazotroph Crocosphaera watsoniiProc. Natl. Acad. Sci. doi:10.1073/pnas.1006943108. Supplemental Materials and Dataset.

Louie L. Wurch, Erin M. Bertrand, Mak A. Saito, Benjamin A.S. Van Mooy and Sonya T. Dyhrman. 2011. Proteome changes driven by phosphorus stress and recovery in the brown tide-forming alga, Aureococcus anophagefferens. PLoS One.

E. M. Bertrand*, M.A. Saito, P.A. Lee, R.B. Dunbar,G.R. DiTullio. 2011. Iron limitation of springtime bacterial and phytoplankton community in the Ross Sea: implications for vitamin B12 nutrition.  Frontiers in Aquatic Microbiology.

Thompson, A.W. *, K. Huang, M.A. Saito, S.W. Chisholm. 2011. Transcriptome response of high and low-light adapted Prochlorococcus strains to changing iron availability. ISME Journal.  1-15.   

Erin M. Bertrand, Mak A. Saito, Young Jae Jeon and Brett A. Neilan. 2011., Vitamin B12 biosynthesis gene diversity in the Ross Sea: the identification of a new group of putative polar B12 biosynthesizersemi, Environmental Microbiology, doi:10.1111/j.1462-2920.2011.02428.x

Jill A. Sohm, Jason Hilton, Abigail Noble, Jonathan P. Zehr, Mak A. Saito, Eric A. Webb. 2011. Nitrogen fixation in the South Atlantic Gyre and the Benguela upwelling system. Geophysical Research Letters.

Gobler, C.J. et al (and 29 others). 2011. Niche of harmful alga, Aureococcus Anophagefferens, revealed through ecogenomics. In Press at Proc. Natl. Acad. Sci. 108.11: 4352-4357..

Higgins, M.B., F.L. Wolfe-Simon, R.S. Robinson, Y. Qin, M.A. Saito and A. Pearson. 2011. Paleoenvironmental implications of taxonomic variation among δ15N values of chloropigments. 75:22. 7351-7363. Geochimica et Cosmochimica Acta.

Sedwick, P. N., C. M. Marsay, A. M. Aguilar-Islas, M. C. Lohan, B. M. Sohst, M. C.Long, K. R. Arrigo, R. B. Dunbar, M. A. Saito, W. O. Smith and G. R. DiTullio. 2011. Early-season depletion of dissolved iron in the Ross Sea polynya: Implications for iron dynamics on the Antarctic continental shelf. Journal of Geophysical Research. 116:C12019.


Saito, M.A., T.J. Goepfert, A.E. Noble, P.N. Sedwick, G.R. DiTullio.  2010. A Seasonal Study of Dissolved Cobalt in the Ross Sea of Antarctica: Micronutrient Control, Absence of Observed Scavenging, and Relationships with Zn, Cd, and P. Biogeosciences.7. 4059-4082.

Wu, Z., B.D. Jenkins, T.A. Rynearson, S.T. Dyhrman, M.A. Saito, M. Mercier, L. Whitney. 2010. Empirical Bayes Analysis of Sequencing-based Transcriptional Profiling without Replicates. BMC Bioinformatics. 11:564. doi:10.1186/1471-2105-11-564.

    Less Nickel for more Oxygen - Nature News and Views 2009
    M.A. Saito, Nature, Vol. 458, 9 April 2009.
    (pdf format)

    Cobalt, manganese, and iron near the Hawaiian Islands: A potential concentrating mechanism for cobalt within a cyclonic eddy and implications for hybrid-type trace metals
    A.E. Noble, M.A. Saito, K. Maiti, C. Benitez-Nelson, Deep Sea Research II, 2008.
    (pdf format)

    Zinc-cobalt colimitation in Phaeocystis antarctica
    Saito, M.A. and T.J. Goepfert., Limnology and Oceanography, 53(1), 2008.
    (pdf format)

    Some thoughts on the concept of co-limitation: Three definitions and the importance of bioavailability
    Saito, M.A., T.J. Goepfert, and J.T. Ritt, Limnology and Oceanography, 53(1), 2008, 276–290.
    (pdf format)

    Regional distributions of nitrogen-fixing bacteria in the Pacific Ocean
    Church, Matthew J., Karin M. Björkman, David M. Karl, Mak A. Saito, and Jonathan P. Zehr, Limnology and Oceanography, 53(1), 2008, 63–77.
    (pdf format)

    Zinc isotope fractionation during high-affinity and low-affinity zinc transport by the marine diatom Thalassiosira oceanica
    John, Seth G., Robert W. Geis, Mak A. Saito, and Edward A. Boyle, Limnology and Oceanography, 52(6), 2007, 2710–2714.
    (pdf format)

    Vitamin B12 and iron co-limitation of phytoplankton growth in the Ross Sea
    E.M. Bertrand*, M.A. Saito*, J.M. Rose, C.R. Riesselman, M.C. Lohan, A.E. Noble, P.A. Lee, G.R. DiTullio (* co-authors), Limnology and Oceanography, 52(3), 2007, 1079–1093.
    (pdf format)

    Survival and growth of two heterotrophic hydrothermal vent archaea, Pyrococcus strain GB-D and Thermococcus fumicolans, under low pH and high sulfide concentrations in combination with high temperature and pressure regimes
    Edgcomb, V.P., Molyneaux, S.J., Böer, S., Wirsen, C.O., Saito, M., Atkins, M.S., Lloyd, K., Teske, A., Extremophiles, 2007, 11:329–342.
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    Examination of precipitation chemistry and improvements in precision using the Mg(OH)2 preconcentration ICP-MS method for high-throughput analysis of open-ocean Fe and Mn in seawater
    Mak A. Saito and David L. Schneider, Analytica Chimica Acta, 565, 2006, 222–233.
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    Iron Storage and DNA-Binding Dps Protein from Trichodesmium erythraeum
    M. Castruita, M. Saito, P. C. Schottel, L. A. Elmegreen, S. Myneni, E. I. Stiefel and F. M. M. Morel,  Applied and Environmental Microbiology, April 2006, p. 2918–2924.
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    A Cadmium Enzyme from a Marine Diatom
    Todd Lane*, Mak Saito*, Graham George, Ingrid Pickering, Roger Prince, Francois Morel* (co-first authors), Nature, May 5, 2005.
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    Production of cobalt binding ligands in a Synechococcus feature at the Costa Rica upwelling dome
    Mak A. Saito, Gabrielle Rocap, James W. Moffett, Limnology and Oceanography, 50(1), 2005, 279–290.
    (pdf format)

    Cobalt and nickel in the Peru upwelling region: A major flux of labile cobalt utilized as a micronutrient
    Mak A. Saito, James W. Moffett, Giacomo R. DiTullio, Global Biogeochemical Cycles, Vol. 18, 2004.
    (pdf format)

    Sulfide Ameliorates Metal Toxicity for Deep-Sea Hydrothermal Vent Archaea
    V.P. Edgcomb, S.J. Molyneaux, M.A. Saito, K. Lloyd, S. Böer, C.O. Wirsen, M.S. Atkins and A. Teske, Applied and Environmental Microbiology, April 2004, p. 2551–2555.
    (pdf format)

    Analysis of whole genome sequence of the centric diatom Thalassiosira pseudonana
    E.V. Armbrust, J.A. Berges, C. Bowler, B.R. Green, D. Martinez, N.H. Putnam, S. Zhou, A.E. Allen, K.E. Apt, M. Bechner, M.A. Brzezinski, B.K. Chaal, A. Chiovitti, A.K. Davis, M.S. Demarest, J.C. Detter, T. Glavina, D. Goodstein, M.Z. Hadi, U. Hellsten, M. Hildebrand, B.D. Jenkins, J. Jurka, V.V. Kapitonov, N. Kröger, W.W.Y. Lau, T.W. Lane, F.W. Larimer, J.C. Lippmeier, S. Lucas, M. Medina, A. Montsant, M. Obornik, M.S. Parker, B. Palenik, G.J. Pazour, P. M. Richardson, T.A. Rynearson, M.A. Saito, D.C. Schwartz, K.Thamatrakoln, K. Valentin, A.Vardi, F.P. Wilkerson, D. S. Rokhsar, Science, Vol. 306, 1 October 2004.
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    The bioinorganic chemistry of the ancient ocean: the co-evolution of cyanobacterial metal requirements and biogeochemical cycles at the Archean-Proterozoic boundary?
    Mak A. Saito, Daniel, M. Sigman, Francois M.M. Morel, Inorganica Chimica Acta, 356, 2003, 308-318.
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    Marine Bioinorganic Chemistry: The Role of Trace of Metals in the Oceanic Cycles of Major Nutrients
    Morel, F.M.M., A.J. Milligan. M.A. SaitoTreatise on Geochemistry, 2003.
    (pdf format)

    Temporal and Spatial Variability of Cobalt in the Atlantic Ocean
    Mak A. Saito and J.W. Moffett, Geochimica et Cosmochimica Acta, Vol. 66, No. 11, pp. 1943–1953, 2002.
    (pdf format)

    Cobalt uptake in Prochlorococcus
    M.A. Saito, J.W. Moffett, S.W. Chisholm, J.B. Waterbury, Limnology and Oceanography, 47(6), 2002, 1629–1636.
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    Tolerance of flagellated protozoa to extreme environmental conditions potentially encountered at deep-sea hydrothermal vents
    Atkins, M.S.; M.A. Hanna, E.A. Kupetsky, M.A. Saito, C.D. Taylor, C.O., Marine Ecology Progress Series, Vol. 226: 63–75, 2002.
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    Complexation of cobalt by natural organic ligands in the Sargasso Sea as determined by a new high-sensitivity electrochemical cobalt speciation method suitable for open ocean work
    Mak A. Saito and J.W. Moffett, Marine Chemistry, 75, 2001, 49–68.
    (pdf format)

    Last updated: September 16, 2015

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