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"Determining the Resistance of Marine Animals to Environmental Chemicals"

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Dr. Mark Hahn, WHOI, Biology Department
Dr. Hahn’s major research interests include receptor-mediated mechanisms of toxicity, and means of adaptation and acquired resistance to exposure to persistent organic pollutants. This presentation centered on looking at toxins in the marine environment, particularly dioxins, PCBs, POPs: the mechanisms of toxicity, what makes animals resistant, genetic markers for resistance.

Web-based Resources

Mark Hahn's web site

NPR report on dioxin-resistant killifish from New Bedford Harbor

Dioxins-R-Us (general information and web sites on dioxin research)

Dioxin information

Endocrine Disruptor Screening and Testing Advisory Committee (EDSTAC) Final Report

Fooling with Nature (PBS Frontline)

Tulane University Center for Bioenvironmental Research

Chlorine Chemistry Council

EPA Endocrine Disruptor Screening Program web site

National Institute of Environmental Health Sciences, endocrine disruptors

Marine Environmental Research Institute (MERI)

Silent Spring Institute

EPA Superfund Cleanup (for students)

Endocrine Disruption in Wildlife Populations, by Woods Hole Sea Grant

Research Update: Contaminants in the Marine Environmnet and their Effects on Marine Mammals, by Woods Hole Sea Grant

The Link Between Environmental Contaminants and Animal Susceptibility
Crago, T.I.
In: Two if by Sea, Vol. 4, No. 1, 2 pp.
Available online:

Nor'easter Researcher Profile: Using Biomarkers to Detect Contamination of the Marine Environment
Hahn, M.E.
In: Nor'easter, Vol. 6, No. 1, pp. 8-11 Spring/Summer 1994

Evolution of Pathways for Chemical Sensing, Response, & Adaptation
Hahn, M.E.
In: Woods Hole Oceanographic Institution 1998 Annual Report, 2 pp.

Dioxin Toxicology and the Aryl Hydrocarbon Receptor: Insights from Fish and Other Non-traditional Models
Hahn, M.E.
In: Mar. Biotechnol., Vol. 3, pp. S224-S238 2001

Formation of a Biological Company, from Access Excellence @ the National Health Museum

Survival in the Sea, from Secrets of the Ocean Realm

Serial Dilutuion & PPM (activity), from the Advanced Technology Environmental Education Center

We All Live Downstream (activity), from Access Excellence @ the National Health Museum

Acquired Resistance to Ah Receptor Agonists in a Population of Atlantic Killifish (Fundulus heteroclitus) Inhabiting a Marine Superfund Site: In Vivo and In Vitro Studies on the Inducibility of Xenobiotic Metabolizing Enzymes
Bello, S.M., D.G. Franks, J.J. Stegeman, and M.E. Hahn
In: Toxicological Sciences, Vol. 66, pp. 77-79 2001

cDNA Cloning and Characterization of a High Affinity Aryl Hydrocarbon Receptor in a Cetacean, the Beluga, Delphinapterus leucas
Jensen, B.A. and M.E. Hahn
In: Toxicological Sciences, Vol. 64, pp. 45-56 2001

cDNA Cloning and Characterization of an Aryl Hydrocarbon Receptor from the Harbor Seal (Phoca vitulina): A Biomarker of Dioxin Susceptibility?
Kim, E.-Y. and M.E. Hahn
In: Aquat. Toxicol., Vol. 58, pp. 57-73 2002

Last updated: June 24, 2014

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