Supplemental information for Figure 3 of Hahn, M.E., Karchner, S.I., Shapiro, M.A., and Perera, S.A. (1997) Molecular evolution of two vertebrate aryl hydrocarbon (dioxin) receptors (AHR1 and AHR2) and the PAS family. Proc. Natl. Acad. Sci. U.S.A. 94: 13743-13748
CLUSTAL W(1.60) multiple sequence alignment of PAS domains. For abbreviations and GenBank accession numbers, see Table 2 of Hahn et al. paper cited above.
hAhR
---QALNGFVLVVTTD-ALVFYASSTIQDYLGF--QQSDVIHQSVYELIHTEDRAEFQRQ
mAhR
---QALNGFVLVVTAD-ALVFYASSTIQDYLGF--QQSDVIHQSVYELIHTEDRAEFQRQ
rAhR
---QALNGFVLVVTAD-ALVFYASSTIQDYLGF--QQSDVIHQSVYELIHTEDRAEFQRQ
fAhR1
---QALNGFVLVITAD-GTIFYSSHTIQDYLGF--HQTDVIHQSAYELVHTEDQQELRRN
fAhR2
---QALNGFVLVVTSE-GMVFYASPTIKDYLGF--HQSDVVHQSVFELIHTDDRAMFREQ
dfAHR1
---------VLVITAE-GLVFYVSSTIQDYLGF--HQSDIIHQSVFELIHTEDRAEFRRQ
dfAHR2
---------ILVVTAE-GYVFYTSPTIQDYLGF--HQSDVVHQSVFELIHTDDRATFRHQ
skateAhR
---------VLVVTAE-GDIFYTSPTVQDYLGF--HQTAVMHQPVFELIHPDDRDEFQRQ
lampAHR
---------VLVVTAE-GLVFYVSHTIQEYLGF--HQCDVVHQSVYELVHSEDRYEFLRQ
dSIM
---QTLDGFIFVVAPD-GKIMYISETASVHLGL--SQVELTGNSIFEYIHNYDQDEMNAI
mSIM1
---QTLDGFIFVVAPD-GKIMYISETASVHLGL--SQVELTGNSIYEYIHPADLDEMTAV
mSIM2
---QTLDGFVFVVASD-GKIMYISETASVHLGL--SQVELTGNSIYEYIHPSDHDEMTAV
hHIF-1a
---KALDGFVMVLTDD-GDMIYISDNVNKYMGL--TQFELTGHSVFDFTHPCDHEEMREM
dSimilar
---QTMDGFLLVLSHE-GDITYVSENVVEYLGI--TKIDTLGQQIWEYSHQCDHAEIKEA
hSRC-1
---EALDGFFFVVNCE-GRIVFVSENVTSYLGY--NQEELMNTSVYSILHVGDHAEFVKN
hTIF2
---EALDGFFFVVNLE-GNVVFVSENVTQYLRY--NQEELMNKSVYSILHVGDHTEFVKN
BMAL1a
---RAADGFLFVVGCDRGKILFVSESVFKILNY--SQNDLIGQSLFDYLHPKDIAKVKEQ
MOP2
---KALEGFIAVVTQD-GDMIFLSENISKFMGL--TQVELTGHSIFDFTHPCDHEEIREN
JAP3/MOP3
---RAADGFLFVVGCDRGKILFVSESVFKILNY--SQNDLIGQSLFDYLHPKDIAKVKEQ
MOP4/NPAS2
---EALDGFIIAVTTD-GSIIYVSDSITPLLGH--LPSDVMDQNLLNFLPEQEHSEVYKI
clock
--LEALDGFFLAIMTD-GSIIYVSESVTSLLEH--LPSDLVDQSIFNFIPEGEHSEVYKI
MOP5/NPAS1
---QSLDGFVFALNQE-GKFLYISETVSIYLGL--SQVEMTGSSVFDYIHPGDHSEVLEQ
mARNT1
---EAADGFLFIVSCETGRVVYVSDSVTPVLNQ--PQSEWFGSTLYDQVHPDDVDKLREQ
mARNT2
---EAADGFLFVVAAETGRVIYVSDSVTPVLNQ--PQSEWFGSTLYEQVHPDDVEKLREQ
rtARNTb
---EAADGFLFVVSCESGRVVYVSDSLTPVLNQ--SQSDWLGSSLYDQLHPDDGDKLREQ
dTRH
---QSLDGFALAVAAD-GRFLYISETVSIYLGL--SQVEMTGSSIFDYIHQADHSEIADQ
dPER
--------FCCVISMHDGIVLYTTPSITDVLGY--PRDMWLGRSFIDFVHLKDRATFASQ
CEC15C8.2
---KALRGFMLMVTRS-GKILHVSDNASEYLGHSVEEIMCQGDSIYDLVDGRDHGAVQAE
CEC41G7.5
---KSLGGFILVLNDN-GEIYYASENVENYLGF--HQSDVLHQPVYDLIHSEDRDDIRQQ
CET01D3.2
---DLLDGFFVILDRR-GDVLYISETISIYLGL--SQVEMTGNAMVDYIHEQDINCFNSA
CEC25A1.11
---EAANGFLFVVCCQTGKVLYVADSITPVLNL--KQEDWLQRNLNELIHPDDQDKIRDQ
MESPHY1b
RLIETATAPILAVDSL-GCVNGWNAKVSELTGL--PVSEAMGKSLVKDLVQRESREAVER
phyA
RLIETATVPILAVDSD-GLVNGWNTKIAELTGL--SVDEAIGKHFLTLVED-SSVEIVKR
kinA
--LQTKTDIHAVLASN-GRIIYISANSKLHLGY--LQGEMIGSFLKTFLHEEDQFLVESY
hAhR
LHWALNPSQC--------------------TESGQGIEEATGL----PQTVVCYNPDQIP
mAhR
LHWALNP------------------------DSAQGVDEAHGP----PQAAVYYTPDQLP
rAhR
LHWALNPSQC--------------------TDSAQGVDETHGL----PQPAVYYTPDQLP
fAhR1
LHWALNPPQA--------------------AASVISQDSSQEMEPDSSSSLVTYNPEQLP
fAhR2
LHFALNPPP-------------------------VASDAEFSQG---CAKAVMYNPEQLP
dfAHR1
LHWALNPTS-------------------------DPESAETGL----TLPIAHYSPEQLP
dfAHR2
LHWALNPQSC--------------------QESNPQADIIPENS-SLCSNVVNYNPHNLP
skateAhR
LHWALNPSAL--------------------STARRSGAGAGTR----RDVVVSYDPQQLP
lampAHR
LHWALKPPP----------------------AAREAHKDGSGDQDASTSSVAVYNPQQLP
dSIM
LSLHPH-------------------------INQHPLAQTHTPIGSPNGVQHPSAYDHDR
mSIM1
LTAHQP-------------------------YHSHFVQEY--------------------
mSIM2
LTAHPP-------------------------LHHHLLQEY--------------------
hHIF-1a
LTHRNG-------------------------LVKKGKEQN--------------------
dSimilar
LSLKRELA----------------------QKVKDEPQQNSG------------------
hSRC-1
LLPKSLVN-------------------------GVPWPQE-------------------A
hTIF2
LLPKSIVN-------------------------GGSWSGE-------------------P
BMAL1a
LSSSDTAP------------------------RERLIDAKTGLP-------VKTDITPGP
MOP2
LSLKNGSG-----------------------FGKKSKDMS--------------------
JAP3/MOP3
LSSSDTAP------------------------RERLIDAKTGLP-------VKTDITPGP
MOP4/NPAS2
LSSHMLVTD----------------------SPSPEYLKSDGD---LEFYCHLLRGSLNP
clock
LSTHLLESD----------------------SLTPEYLKSKNQ---LEFCCHMLRGTIDP
MOP5/NPAS1
LGLRTPTPGP--------------------PTPPSVSSSSSSSSSLADTPEIEASLTKVP
mARNT1
LSTSENAL------------------------TGRVLDLKTGT--------VKKEGQQSS
mARNT2
LCTSENSI------------------------TGRILDLKTGT--------VKKEGQQSS
rtARNTb
LSTAESNN------------------------TGRMLDLKTGT--------VKKEGQQSS
dTRH
LGLSLTSGGGGGGGGSSSSGGGGGGAGGGMASPTSGASDDGSGTHGTNNPDVAASMTQAS
dPER
ITTGIPIAE---------------------SRGSVPKDAKS-----------TFCVMLRR
CEC15C8.2
LASGPPG--------------------------AATFPEE--------------RVFICR
CEC41G7.5
LDSNFHIP----------------------TSSASNQFDVFAP-----------------
CET01D3.2
LNYCDLNWP---------------------QMCNVRVKSSLTKRAN-KDAVRASPGYKVL
CEC25A1.11
LCGSEVS-------------------------VNKVLDLKSGS--------VKREG--AS
MESPHY1b
VLYMALN---------------------------GEEEQN-----------VEIQLKTWG
phyA
MLENALE---------------------------GTEEQN-----------VQFEIKTH-
kinA
FYNEHHLMPCTFR-------------FIKKDHTIVWVEAAVEIVTTRAERTEREIILKMK
hAhR
PENSPLMERCFICRLRCLLDNSS----------GFLAMNF--------QGKLKYLHGQK-
mAhR
PENASFMERCFRCRLRCLLDNSS----------GFLAMNF--------QGRLKYLHGQN-
rAhR
PENTAFMERCFRCRLRCLLDNSS----------GFLAMNF--------QGRLKYLHGQN-
fAhR1
PENSSFLERNFVCRFRCLLDNSS----------GFLALNI--------QGRLKFLHGQN-
fAhR2
PDSSSFLERSFVCRFRCLLDNSS----------GFLALKF--------HGRLKYLQGQN-
dfAHR1
PENSPFLERNFVCRLRCLLDNSS----------GFLAMNF--------QGRLKFLYEQN-
dfAHR2
PENSSFMKRNFICRFRCLLDNSS----------GFLTLNF--------QGRLKFLHGQN-
skateAhR
PENSTFMERTFVCKMRSLLNSSS----------GYVALSI--------EGRLKYLHGQN-
lampAHR
PENSSFLERQFICRFRCLLDNSS----------GFLALQM--------QGRLKFLHGQN-
dSIM
GSHTIEIEKTFFLRMKCVLAKR-----------N--AGLT--------TSGFKVIHCSG-
mSIM1
-----EIERSFFLRMKCVLAKR-----------N--AGL---------CGGYKVIHCSG-
mSIM2
-----EIERSFFLRMKCVLAKR-----------N--AGLT--------CSGYKVIHCSG-
hHIF-1a
------TQRSFFLRMKCTLTSR-----------GRTMNIK--------SATWKVLHCTG-
dSimilar
---VSTHHRDLFVRLKCTLTSR-----------GRSINIK--------SASYKVIHITG-
hSRC-1
TR---RNSHTFNCRMLIHP-PD----------EPGTENQE-------ACQRYEVMQCFTV
hTIF2
PR---RNSHTFNCRMLVKPLPDS--------EEEGHDNQE-------AHQKYETMQCFAV
BMAL1a
SRLCSGARRSFFCRMKCNR-PS---VKVEDKDFPSTCSKK-----KADRKSFCTIHSTGY
MOP2
------TERDFFMRMKCTVTNR-----------GRTVNLK--------SATWKVLHCTG-
JAP3/MOP3
SRLCSGARRSFFCRMKCNR-PS---VKVEDKDFPSTCSKK-----KADRKSFCTIHSTGY
MOP4/NPAS2
KEFPTYEYIKFVGNFRSYNNVP-----------SPSCNGF--------DNTLSRPCRVP-
clock
KEPSTYEYVRFIGNFKSLTSVS-----------TSTHNGF--------EGTIQRTHRPS-
MOP5/NPAS1
PSSLVQ-ERSFFVRMKSTLTKR-----------G--LHVK--------ASGYKVIHVTG-
mARNT1
MRMCMGSRRSFICRMRCGTSSVDP-VSMNRLSFLRNRCRNGLGSVKEGEPHFVVVHCTGY
mARNT2
MRMCMGSRRSFICRMRCGNAPLDH-LPLNRITTMRKRFRNGLGPVKEGEAQYAVVHCTGY
rtARNTb
VRMCMGARRSFICRMRCGSCPVEP-MSMNRLNFLRSRNRNGLGPPKDGEPQYVVVHCTGY
dTRH
TSGYKGYDRSFCVRMKSTLTKR-----------G--CHFK--------SSGYRASDATSN
dPER
YRGLKSGGFGVIGRPVSYEPFR----------LGLTFREAP------EEARPDNYMVSN-
CEC15C8.2
LNLARTAKRQLQYHKFVLFQGR--------------YIQP--------AEFYQQLNAQN-
CEC41G7.5
-QNSKYLERNVNARFRCLLDNTC----------GFLRIDM--------RGKLMSLHGLP-
CET01D3.2
RLEITMGPNTNTRMIACYPMPTP---------VLSTVTIP--------SNSFVIITSID-
CEC25A1.11
TRVHMSCRRGFICRMRVG--------ALEPLHRLRNR-RP---LFQHAGQNYVVMHCTGY
MESPHY1b
PQLHSHGGTVILVVNACAS--R-----------DVSESVV--------GVCFVGQDVTG-
phyA
-LSRADAGPISLVVNACAS--R-----------DLHENVV--------GVCFVAHDLTG-
kinA
VLEEETGHQSLNCEKHEIEPASPESTTYITDDYERLVENLPSPLCISVKGKIVYVNSAML
hAhR
---------------------------KKGKD---------GSILPPQLALFAIATPLQP
mAhR
---------------------------KKGKD---------GALLPPQLALFAIATPLQP
rAhR
---------------------------KKGKD---------GALLPPQLALFAIATPLQP
fAhR1
---------------------------QQREN---------GGKATPQLALFAIATPLQP
fAhR2
---------------------------LCKDI---------ETCKKVQLALFAIAMPVQP
dfAHR1
---------------------------MKGKD---------GSCVPPQLALFAIATPLQP
dfAhR2
---------------------------KKAED---------GTPIPPQLALFAVATPLQP
skateAhR
---------------------------KRAED---------GSLLPPQLALFAIATPLQV
lampAHR
---------------------------RRSAD---------GSLQPAQLALFAVATPLQS
dSIM
--------------------------YLKARIYPD--RGDGQGSLIQNLGLVAVGHSLPS
mSIM1
--------------------------YLKIRQYSL--DMSPFDGCYQNVGLVAVGHSLPP
mSIM2
--------------------------YLKIRQYML--DMSLYDSCYQIVGLVAVGQSLPP
hHIF-1a
--------------------------HIHVYDTNS-NQPQCGYKKPPMTCLVLICEPIPH
dSimilar
---------------------------------------HLVVNAKGERLLMAIGRPIPH
hSRC-1
SQ------------------------PKSIQED--------GEDFQSCLICIARRLPRP-
hTIF2
SQ------------------------PKSIKEE--------GEDLQSCLICVARRVPMKE
BMAL1a
LKSWPPT-------------------KMGLDEDNE--PDNEGCNLSCLVAIGRLHSHVVP
MOP2
--------------------------QVKVYNNCPPHNSLCGYKEPLLSCLIIMCEPIQH
JAP3/MOP3
LKSWPPT-------------------KMGLDEDNE--PDNEGCNLSCLVAIGRLHSHVVP
MOP4/NPAS2
-----------------------------------------LGKEVCFIATVRLATPQFL
clock
-----------------------------------------YEDRVCFVATVRLATPQFI
MOP5/NPAS1
------------------------------------------RLRAHALGLVALGHTLPP
mARNT1
IKAWPPA-------------------GVSLPDDDP--EAGQGSKF-CLVAIGRLQVTSSP
mARNT2
IKAWPPA-------------------GMTIPEEDA--DVGQGSKY-CLVAIGRLQVTSSP
rtARNTb
IKSWPPT-------------------GVNLTDEEA--DNILGSRY-CLVAIGRLQVTSCP
dTRH
CNNGNNASNNAKNVKNPGSNYSVVLLLCKLRPQYT--FSHSRKSQPPLLGMVALAIALPP
dPER
-----------------------------------------GTNMLLVICATPIKSSYKV
CEC15C8.2
-----------------------------------------SQPDCDQPVFSAYCQPLIN
CEC41G7.5
--------------------------SSYVMG---------RTASGPVLGMICVCTPFVP
CET01D3.2
----------------------------------------LHITFADEKAHQLLNNPFYP
CEC25A1.11
IKNAPPQ-------------------GINAPASS------------CLVAIARLQVASMP
MESPHY1b
--------------------------EKEVLDK-------FIRIQGDYTTIVRSRNSLIP
phyA
--------------------------QKTVMDK-------FTRIEGDYKAIIQNPNPLIP
kinA
SMLGAKSKD----------AIIGKSSYEFIEEEYHDIVKNRIIRMQKGMEVGMIEQTWKR
hAhR
----PSILEIRTK--NFIFRTKHKLDFTPIGCDAKG--RIVLG--YTEAELCTRG-----
mAhR
----PSILEIRTK--NFIFRTKHKLDFTPIGCDAKG--QLILG--YTEVELCTRG-----
rAhR
----PSILEIRTK--NFIFRTKHKLDFTPIGCDAKG--QLILG--YTEVELCNKG-----
fAhR1
----PSILEIRTK--NMIFRTKHKLDFTPLACDAKG--KIVLG--YTEAELRVRG-----
fAhR2
----PSIVEIRAK--MLLFQTRHKLDFTPTGVDTRG--KAILG--YTEIELCMKG-----
dfAHR1
----PSILEIRTK--NFIFRTKHKLDFTPMGCDAKG--KIVLG--YTEAELCMRG-----
dfAhR2
----PSILEVRTK--MLIFQTKHKLDFTPLACDTKG--KFVLG--YTETELCMRG-----
skateAhR
----PAILEIRTR--SALFQTKHKLDFSPVACDAKA--RIVLG--YSELELCMRG-----
lampAHR
----PSILEIRTR--NIIFRTKHKLDFTPIGCDAKG--RIVLG--YTELELAMRG-----
dSIM
----SAITEIKLH--QNMFMFRAKLDMKLIFFDARV--SQLTG--YEPQDLIEK------
mSIM1
----SAVTEIKLH--SNMFMFRASLDMKLIFLDSRV--AELTG--YEPQDLIEK------
mSIM2
----SAITEIKLH--SNMFMFRASLDLKLIFLDSRV--TELTG--YEPQDLIEK------
hHIF-1a
----PSNIEIPLD--SKTFLSRHSLDMKFSYCDERI--TELMG--YEPEELLGR------
dSimilar
----PSNIEIPLG--TSTFLTKHSLDMRFTYVDDKM--HDLLG--YLPKDLLDT------
hSRC-1
----PAITGV-----E-SFMTKQDTTGKIISIDTSS--LRAAG--RTGWEDLVRK-----
hTIF2
R---PVLPSS-----E-SFTTRQDLQGKITSLDTST--MRAAM--KPGWEDLVRR-----
BMAL1a
Q---PVNGEIRVK--SMEYVSRHAIDGKFVFVDQRA--TAILA--YLPQELLGT------
MOP2
----PSHMDIPLD--SKTFLSRHSMDMKFTYCDDRI--TELIG--YHPEELLGR------
JAP3/MOP3
Q---PVNGEIRVK--SMEYVSRHAIDGKFVFVDQRA--TAILA--YLPQELLGT------
MOP4/NPAS2
----KEMCIVDEP--LEEFTSRHSLEWKFLFLDHRA--PPIIG--YLPFEVLGT------
clock
----KEMCTVEEP--NEEFTSRHSLEWKFLFLDHRA--PPIIG--YLPFEVLGT------
MOP5/NPAS1
----APLAELPLH--GHMIVFRLSLGLTILACESRV--SDHMD--LGPSELVGR------
mARNT1
N---CTDMSNICQ--PTEFISRHNIEGIFTFVDHRC--VATVG--YQPQELLGK------
mARNT2
V---CMDMSGMSV--PTEFLSRHNSDGIITFVDPRC--ISVIG--YQPQDLLGK------
rtARNTb
S---DTDMNSISV--PVEFISRHNCQGLFTFVDHRC--MATVG--YQPQELLGK------
dTRH
----PSVHEIRLE--CDMFVTRVNFDLRVAHCEPRV--SDLLD--YSPEDLVNK------
dPER
P---DEILS--QK--SPKFAIRHTATGIISHVDSAA--VSALG--YLPQDLIGR------
CEC15C8.2
----PENAEGMSTGNTHVFSTQHYLDMKFKEADTMA--SQHLG--FSKEQLKGM------
CEC41G7.5
----PSTSDLASE--DMILKTKHQLDGALVSMDQKV--YEMLE--IDETDLPMP------
CET01D3.2
----DSNIKGMSL--YSLIDISDSEVISKMHFDIFN--LGAYK--TPYYRMILNQ-----
CEC25A1.11
V---CADP---TS--TNQFSVRVSEDGKMTFIDARV--SDLIG--LSSDQLIGR------
MESPHY1b
----PIFGS---D--EYGCCTEWNPAMEKLTGVRRE--DVIGR--MLMGDVFG-------
phyA
----PIFGT---D--EFGWCTEWNPAMSKLTGLKRE--EVIDK--MLLGEVFGTQ-----
kinA
LDGTPVHLEVKAS--PTVYKNQQAELLLLIDISSRKKFQTILQKSRERYQLLIQNSIDTI
hAhR
-------------SGYQFIHAA---DML---YCAESHIRMIK--TGESGM----------
mAhR
-------------SGYQFIHAA---DIL---HCAESHIRMIK--TGESGM----------
rAhR
-------------SGYQFIHAA---DML---HCAESHIRMIK--TGESGM----------
fAhR1
-------------SGYQFIHAA---DML---YCAENHVRMIK--TGESGL----------
fAhR2
-------------SGYQFIHAA---DMM---YCADNHIRMIK--TGESGL----------
dfAHR1
-------------SGYQFIHAA---DMM---YCAENHVRMMK------------------
dfAhR2
-------------TGYQFIHAA---DMM---YCADNHVKMI-------------------
skateAhR
-------------SGYQFIHAH---DMV---YCADNHVRLM-------------------
lampAHR
-------------TGYQFIHAA---DML---HCADNHVRMM-------------------
dSIM
-------------TLYQYIHAA---DIM---AMRCSHQILLY--KGQVTTKY--------
mSIM1
-------------TLYHHVHGC---DTF---HLRCAHHLLLV--KGQVTTKY--------
mSIM2
-------------TLYHHVHGC---DTF---HLRYAHHLLLV--KGQVTTKY--------
hHIF-1a
-------------SIYEYYHAL---DSD---HLTKTHHDMFT--KGQVTTGQ--------
dSimilar
-------------SLFSCQHGA---DSE---RLMATFKSVLS--KGQGETSRY-------
hSRC-1
-------------CIYAFFQPQ-GREPS---YARQLFQEVMT--RGTASSPSYRFILNDG
hTIF2
-------------CIQKFHAQHEGESVS---YAKRHHHEVLR--QGLAFSQIYRFSLSDG
BMAL1a
-------------SCYEYFHQD---DIG---HLAECHRQVLQT-REKITTNCYKFK----
MOP2
-------------SAYEFYHAL---DSE---NMTKSHQNLCT--KGQVVS----------
JAP3/MOP3
-------------SCYEYFHQD---DIG---HLAECHRQVLQT-REKIT-----------
MOP4/NPAS2
-------------SGYDYYHID---DLE---LLARCHQHLMQFGKGKS------------
clock
-------------SGYDYYHVD---DLE---NLAKCHEHLMQYGKGKS------------
MOP5/NPAS1
-------------SCYQFVHGQ---DAT---RIRQSHVDLLD--KGQVMT----------
mARNT1
-------------NIVEFCHPE---DQQ---LLRDSFQQVVKL-KGQVLSVMFRFR----
mARNT2
-------------DILEFCHPE---DQS---HLRESFQQVVKL-KGQVLSVMYRFR----
rtARNTb
-------------NILELAHPE---DQE---LLRDSFQQVVKL-KGQVLSVMFRFL----
dTRH
-------------SLYSLCHAE---DAN---RLRKSHSDLIE--KGQV------------
dPER
-------------SIMDFYHHE---DLS---VMKETYETVMK--KGQTAGASF-------
CEC15C8.2
-------------SWYGMIHPN---HVP---EIAHKHRLLCQEKEGSVLAL---------
CEC41G7.5
--------------LYNLVHVE---DAV---CMAEAHKEAIK--NGSSGL----------
CET01D3.2
------------TSETFYVESN---IFR---HTSISSKQFND--SITFVSSIL-------
CEC25A1.11
-------------YWWNLAHPA---DEK---TLQDSFVALLSD-QPMRINIRVRTST---
MESPHY1b
-------------SALRLRGSD---GLT---QFMIVLNRAMDG-ADTDKFPF--------
phyA
------------KSCCRLKNQE---AFV---NLGIVLNNAVTS-QDPDKVSFAFF-----
kinA
AVIHNGKWVFMNESGISLFEAATYEDLIGKNIYDQLHPCDHEDVKERIQNIAEQKTESEI
hAhR
-----------------------
mAhR
-----------------------
rAhR
-----------------------
fAhR1
-----------------------
fAhR2
-----------------------
dfAHR1
-----------------------
dfAhR2
-----------------------
skateAhR
-----------------------
lampAHR
-----------------------
dSIM
-----------------------
mSIM1
-----------------------
mSIM2
-----------------------
hHIF-1a
-----------------------
dSimilar
-----------------------
hSRC-1
TM---------------------
hTIF2
TLVAAQTKSKLIRSQTTNEPQLV
BMAL1a
-----------------------
MOP2
-----------------------
JAP3/MOP3
-----------------------
MOP4/NPAS2
-----------------------
clock
-----------------------
MOP5/NPAS1
-----------------------
mARNT1
-----------------------
mARNT2
-----------------------
rtARNTb
-----------------------
dTRH
-----------------------
dPER
-----------------------
CEC15C8.2
-----------------------
CEC41G7.5
-----------------------
CET01D3.2
-----------------------
CEC25A1.11
-----------------------
MESPHY1b
-----------------------
phyA
-----------------------
kinA
-----------------------
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