Hormonally active agents
Ligand-receptor interactions constitute a major mechanism by which chemical-biological interactions are initiated, and provide a focus for our work. The aryl hydrocarbon receptor (Ah receptor) is a ligand-activated transcription factor and the first protein in a signal transduction pathway that culminates in the altered expression of genes involved in the control of cell growth and differentiation. Certain HAH bind to the Ah receptor, triggering this altered gene expression that results in the toxic effects of HAH. The presence and properties of Ah receptors in different animal groups could determine the sensitivity of those groups to HAH effects. We seek to understand the structure and function of the Ah receptor, including its role in determining the ability of marine animals to respond to HAH exposure. Our current research is aimed at the biochemical and molecular characterization of the Ah receptor in non-mammalian vertebrates, including teleost and elasmobranch fish, as well as in marine mammals.
See "Michael Moore publications"
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